ICP-MS法检测化妆品包材中重金属迁移量

Determination of Heavy Metal Migration in Cosmetic Packaging Materials by ICP-MS

摘要: 建立电感耦合等离子体质谱法(ICP-MS)测定化妆品包材中铬、钴、镍、硒、锶、锆、锑、钡、铊等9种元素的迁移量的方法。采用4%乙酸、10%乙醇、90%乙醇作为化妆品模拟液进行迁移实验，模拟液根据基质差异选择不同的前处理方式，优化仪器参数与实验条件，最后使用ICP-MS法测定模拟液中9种元素的含量。各元素在一定的浓度范围内线性关系良好，相关系数均大于0.998，4%乙酸基质模拟液方法检出限为0.1~2.0 ug/L，样品平均加标回收率为94.6%~107.8%，相对标准偏差为0.95%~4.07%；乙醇基质模拟液方法检出限为0.1~2.0 ug/kg，样品平均加标回收率为92.3%~104.8%，相对标准偏差为0.92%~3.95%。该方法有较好的准确度和精密度，适合用于化妆品包材中9种重金属元素迁移量的检测。

Abstract: A method was established for determining the migration of nine elements (chromium, cobalt, nickel, selenium, strontium, zirconium, antimony, barium, and thallium) in cosmetic packaging materials using inductively coupled plasma mass spectrometry (ICP-MS). Migration tests were conducted using 4% acetic acid, 10% ethanol, and 90% ethanol as cosmetic simulants. Different pretreatment methods were applied based on the simulant matrix, and instrument parameters and experimental conditions were optimized. The content of the nine elements in the simulants was then determined by ICP-MS. All elements showed good linear relationships within their respective concentration ranges, with correlation coefficients greater than 0.998. The method detection limits for the 4% acetic acid simulant ranged from 0.1 to 2.0 μg/L, with average spiked recoveries of 94.6%~107.8% and relative standard deviations (RSDs) of 0.95%~4.07%. For the ethanol-based simulants, the method detection limits ranged from 0.1 to 2.0 μg/kg, with average spiked recoveries of 92.3%~104.8% and RSDs of 0.92%~3.95%. The method demonstrated good accuracy and precision and is suitable for detecting the migration of these nine heavy metal elements in cosmetic packaging materials.