地达西尼胶囊治疗卒中后失眠1例诊疗体会并文献复习

Dexadinine Capsules for Post-Stroke Insomnia: A Case Report and Literature Review

摘要: 目的：探讨地达西尼胶囊治疗卒中后失眠的有效性与安全性，为临床诊疗提供参考。方法：回顾性分析1例卒中后失眠患者的诊疗过程，予地达西尼胶囊治疗，并结合文献复习，分析该药的药理特点及临床应用。结果：患者治疗后睡眠质量显著改善，未出现明显不良反应。文献复习显示地达西尼作为新型GABA受体部分激动剂，兼具改善睡眠与减少药物相互作用风险的优势，但目前关于卒中后失眠的治疗案例相关报道有限。结论：地达西尼胶囊可能为卒中后失眠提供一种新的治疗选择，但仍需进一步研究验证。

Abstract: Objective: To investigate the efficacy and safety of Dexadinine Capsules in the treatment of post-stroke insomnia, so as to provide a reference for clinical diagnosis and treatment. Methods: A retrospective analysis was performed on the diagnosis and treatment process of one patient with post-stroke insomnia who was treated with Dexadinine Capsules. Combined with the literature review, the pharmacological characteristics and clinical application of the drug were analyzed. Results: The patient’s sleep quality was significantly improved after treatment, and no obvious adverse reactions occurred. Literature review showed that as a novel partial agonist of GABA receptors, Dexadinine has the advantages of improving sleep and reducing the risk of drug-drug interactions, but there are limited relevant reports on its application in post-stroke insomnia. Conclusion: Dexadinine Capsules may provide a new therapeutic option for post-stroke insomnia, but further research is still needed for verification.