非感染性肉芽肿性全葡萄膜炎1例

A Case of Non-Infectious Granulomatous Panuveitis

摘要: 目的：本文旨在分析非感染性肉芽肿性全葡萄膜炎的临床表现、诊断思路及治疗效果。方法：收治我院1例双眼非感染性肉芽肿性全葡萄膜炎患者的临床资料，包括眼部表现、辅助检查、病原学筛查、治疗方案及随访结果，并结合相关文献进行讨论。患者经静脉激素冲击治疗后葡萄膜炎症状缓解，病情好转后出院。随访3个月，患者病情稳定，视力恢复良好。结论：非感染性肉芽肿性全葡萄膜炎可表现为多种眼部炎症体征，诊断需在充分排除感染因素基础上结合典型眼部体征和辅助检查综合判断。对炎症活动明显者，早期、足量糖皮质激素治疗有助于迅速控制炎症、改善预后；UBM在识别炎症相关瞳孔阻滞及动态评估前节结构变化方面具有重要参考价值。

Abstract: Objective: To analyze the clinical manifestations, diagnostic approach, and therapeutic outcomes of non-infectious granulomatous panuveitis. Methods: The clinical data of one patient with bilateral non-infectious granulomatous panuveitis admitted to our hospital were collected, including ocular manifestations, auxiliary examinations, pathogen screening, treatment regimen, and follow-up outcomes, and were discussed in conjunction with the relevant literature. After intravenous corticosteroid pulse therapy, the uveitic manifestations and related symptoms were rapidly relieved, and the patient was discharged after clinical improvement. During the 3-month follow-up, the condition remained stable and visual acuity recovered well. Conclusion: Non-infectious granulomatous panuveitis may present with various ocular inflammatory signs. Its diagnosis requires a comprehensive assessment based on typical ocular signs and auxiliary examinations after infectious causes have been fully excluded. In patients with marked inflammatory activity, early and adequate corticosteroid therapy can help rapidly control inflammation and improve prognosis. Ultrasound biomicroscopy is of important value in identifying inflammation-related pupillary block and dynamically evaluating anterior segment structural changes.