少腹逐瘀汤联合布洛芬治疗原发性痛经的临床疗效观察

Clinical Observation of Shaofu Zhuyu Decoction Combined with Ibuprofen in the Treatment of Primary Dysmenorrhea

摘要: 目的：分析少腹逐瘀汤治疗原发性痛经的临床效果。方法：纳入2024年6月至2025年12月本院接诊的128例原发性痛经病例作为研究对象，依循随机数字表设定两组队列(各64例)。对照组口服布洛芬，观察组辅以少腹逐瘀汤联合治疗。围绕整体疗效、中医证候积分、疼痛感(VAS评分、CMSS评分)及生化指标(PGE2、PGF2α、β-EP水平)展开对比，并基于网络药理学结合分子对接解析少腹逐瘀汤活性成分治疗原发性痛经的抗炎镇痛分子机制。结果：与对照组疗效的81.25% (52/64)比较，观察组疗效为95.31% (61/64)显著升高(P < 0.05)；治疗后两组月经量少、小腹冷痛、畏寒身冷评分均降低，且与对照组比较，观察组上述中医证候积分变化更明显(P < 0.05)；在月经期间，观察组患者VAS评分及持续时间、严重程度等CMSS评分均低于对照组(P < 0.05)；治疗后两组PGE2、β-EP水平均升高，两组PGF2α水平均降低，且与对照组比较，观察组上述指标变化更明显(P < 0.05)。结论：少腹逐瘀汤通过降低PGF2水平，提升PGE2、β-EP水平，可有效改善原发性痛经患者月经期间疼痛情况，降低中医证候积分，具有良好的临床疗效。

Abstract: Objective: To analyze the clinical effect of Shaofu Zhuyu Decoction in the treatment of primary dysmenorrhea. Methods: 128 cases of primary dysmenorrhea treated in our hospital from June 2024 to December 2025 were included as the research objects, and two groups of queues (64 cases each) were set up according to the random number table. The control group was treated with ibuprofen orally, and the observation group was treated with abdominal Shaofu Zhuyu Decoction. The overall efficacy, TCM syndrome score, pain (VAS score, CMSS score) and biochemical indicators (PGE2, PGF2α, β-EP levels) were compared, and the anti-inflammatory and analgesic molecular mechanism of active components of Shaofu Zhuyu Decoction in the treatment of primary dysmenorrhea was analyzed based on network pharmacology combined with molecular docking. Results: Compared with 81.25% (52/64) of the control group, the curative effect of the observation group was 95.31% (61/64), which was significantly higher (P < 0.05). After treatment, the scores of less menstruation, cold pain in the lower abdomen and chills in the two groups decreased, and compared with the control group, the changes of the above TCM syndrome scores in the observation group were more obvious (P < 0.05). During menstruation, the CMSS scores of VAS score, duration and severity in the observation group were lower than those in the control group (P < 0.05). After treatment, the levels of PGE2 and β-EP in the two groups increased, and the levels of PGF2α in the two groups decreased. Compared with the control group, the changes of the above indexes in the observation group were more obvious (P < 0.05). Conclusion: Shaofu Zhuyu Decoction can effectively improve the pain of patients with primary dysmenorrhea during menstruation and reduce the TCM syndrome score by reducing the level of PGF2 and increasing the levels of PGE2 and β-EP. It has good clinical efficacy.