刺芒柄花素的抗炎、抗肿瘤、抗氧化、 抗抑郁、抗焦虑药理作用
Pharmacological Effects of Formononetin: Anti-Inflammatory, Anti-Tumor, Antioxidant, Antidepressant and Anxiolytic Activities
DOI: 10.12677/acm.2026.1652130, PDF,    科研立项经费支持
作者: 黄曦醇, 权 泉, 李君豪, 宁 钊, 李红叶, 赵文慧, 金成浩*：黑龙江八一农垦大学生命科学技术学院，黑龙江 大庆
关键词: 刺芒柄花素；抗炎；抗肿瘤；抗氧化；抗抑郁；抗焦虑；Formononetin； Anti-Inflammatory； Anti-Tumor； Antioxidant； Antidepressant； Anxiolytic
摘要: 刺芒柄花素是一种广泛存在于黄芪、葛根及鸡血藤等中药材中的异黄酮类植物雌激素。近年来大量研究表明，该化合物具有显著的抗炎、抗肿瘤、抗氧化、抗抑郁及抗焦虑等多种药理活性。本文系统综述刺芒柄花素的药理作用及相关分子机制，并结合其药代动力学特征加以阐述，以期为刺芒柄花素的后续开发与临床合理应用提供理论依据。
Abstract: Formononetin is an isoflavonoid phytoestrogen widely present in Chinese medicinal herbs such as Astragalus membranaceus, Pueraria lobata, and Spatholobus suberectus. Extensive studies in recent years have demonstrated that this compound possesses significant pharmacological activities, including anti-inflammatory, anti-tumor, antioxidant, antidepressant, and anxiolytic effects. This article systematically reviews the pharmacological actions and underlying molecular mechanisms of formononetin, and further discusses its pharmacokinetic characteristics, aiming to provide a theoretical basis for the subsequent development and rational clinical application of this natural active constituent.
文章引用：黄曦醇, 权泉, 李君豪, 宁钊, 李红叶, 赵文慧, 金成浩. 刺芒柄花素的抗炎、抗肿瘤、抗氧化、 抗抑郁、抗焦虑药理作用[J]. 临床医学进展, 2026, 16(5): 3135-3140. https://doi.org/10.12677/acm.2026.1652130

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