去氢骆驼蓬碱药理活性研究进展
Research Progress on Pharmacological Activities of Harmine
DOI: 10.12677/acm.2026.1652131, PDF,    科研立项经费支持
作者: 李红叶, 叶佳茹, 裴慧珍, 任 爽, 贾淋博, 金成浩*：黑龙江八一农垦大学生命科学技术学院，黑龙江 大庆
关键词: 去氢骆驼蓬碱；抗肿瘤；抗炎；抗菌；抗包虫；成骨分化；神经保护；Harmine； Antitumor； Anti-Inflammatory； Antibacterial； Anti-Echinococcal； Osteogenic Differentiation； Neuroprotection
摘要: 骆驼蓬为蒺藜科骆驼蓬属多年生植物，民间多用在咳喘痰壅、关节疼痛、肿毒及肤痒等症的治疗。去氢骆驼蓬碱是从该植物中分离得到的一种生物碱。已有研究显示，去氢骆驼蓬碱具备抗肿瘤、抗炎抑菌、抗包虫、调控成骨分化以及作用于中枢神经系统等多种药理活性。本文围绕去氢骆驼蓬碱的药理作用进行综述，旨为去氢骆驼蓬碱的深入研究与新药开发提供理论支持。
Abstract: Peganum harmala, a perennial herbaceous plant belonging to the Zygophyllaceae family, has been traditionally utilized in the treatment of conditions such as cough, asthma, rheumatic pain, non-specific inflammatory swellings, and pruritic skin disorders. Harmine, an alkaloid derived from Peganum harmala, has been reported to exhibit a wide range of biological activities, including antitumor, anti-inflammatory, antibacterial, anti-echinococcal, osteogenic differentiation regulatory, and neuroprotective effects. This review aims to elucidate the pharmacological properties and underlying molecular mechanisms of harmine, thereby providing a theoretical foundation for further investigation and drug development.
文章引用：李红叶, 叶佳茹, 裴慧珍, 任爽, 贾淋博, 金成浩. 去氢骆驼蓬碱药理活性研究进展[J]. 临床医学进展, 2026, 16(5): 3141-3147. https://doi.org/10.12677/acm.2026.1652131

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