白皮杉醇药理作用及其分子机制的研究进展

Progress on the Pharmacological Effects of Piceatannol and Its Molecular Mechanism

摘要: 白皮杉醇(Piceatannol, PIC)是白藜芦醇的重要结构类似物，属于天然二苯乙烯型多酚，广泛分布于葡萄、百香果、蓝莓、大黄及何首乌等多种植物中。现代药理研究表明，该成分可通过多通路调控发挥抗肿瘤、抗炎、抗病毒及肝脏保护等多重活性。凭借安全性高、作用靶点丰富、毒副作用轻微等优势，白皮杉醇已成为天然药物研发领域的关注焦点。本文系统梳理近年相关研究进展，重点阐述其药理作用与分子机制，旨在为后续深度研究、新药创制及临床转化提供科学参考。

Abstract: Piceatannol (PIC), an important structural analogue of resveratrol, is a naturally occurring stilbene-type polyphenol widely found in various plants such as grapes, passion fruit, blueberries, rhubarb, and Polygonum multiflorum. Modern pharmacological studies have demonstrated that this compound exerts multiple activities, including anti-tumor, anti-inflammatory, antiviral, and hepatoprotective effects, through multi-pathway regulation. Owing to its high safety, abundant action targets, and mild side effects, piceatannol has become a focus of interest in the field of natural drug discovery. This article systematically reviews recent research progress, with an emphasis on its pharmacological effects and molecular mechanisms, aiming to provide a scientific reference for further in-depth studies, new drug development, and clinical translation.