臭椿酮的抗肿瘤作用及其分子机制的研究进展

Research Progress on the Anti-Tumor Effects and Molecular Mechanisms of Ailanthone

摘要: 臭椿为苦木科臭椿属落叶乔木，其药材常用于治疗赤白带下、久泻久痢及崩漏经多等症。从臭椿中分离得到的三萜类化合物臭椿酮，具有抗肿瘤活性。已有研究表明，臭椿酮可通过诱导肿瘤细胞凋亡、抑制细胞侵袭与迁移发挥抗肿瘤作用。本文对臭椿酮的抗肿瘤作用及其分子机制进行系统综述，以期为臭椿酮的深入研究和药物开发提供理论依据。

Abstract: Ailanthus altissima, a deciduous tree belonging to the Simaroubaceae family and the genus Ailanthus, is often used in traditional medicine to treat conditions such as leucorrhea, chronic diarrhea, dysentery, and excessive menstrual bleeding. A triterpenoid compound, ailanthone, isolated from Ailanthus altissima, has been found to possess anti-tumor activity. Previous studies have shown that ailanthone exerts its anti-tumor effects by inducing apoptosis in tumor cells and inhibiting cell invasion and migration. This article provides a systematic review of the anti-tumor effects and molecular mechanisms of ailanthone, with the aim of providing a theoretical basis for further research and drug development of ailanthone.