甘松新酮药理作用及其相关分子机制研究进展

Research Progress on the Pharmacological Effects of Nardosinone and Its Related Molecular Mechanisms

摘要: 甘松新酮是一种天然倍半萜类化合物，其主要来源于败酱科甘松属植物甘松的干燥根茎。近年来，随着药理研究的不断深入，研究者发现甘松新酮具有广泛的药理活性，不仅能够发挥抗类风湿关节炎、抗肿瘤的作用，还在抗心律失常、改善抑郁状态以及保护心肌细胞等多个方面展现出良好的应用潜力。为系统梳理甘松新酮的研究现状，本文综述了其药理作用及机制的相关研究进展，以期为甘松新酮的进一步研究和药物开发提供理论基础。

Abstract: Nardosinone is a natural sesquiterpene compound, mainly derived from the dried rhizomes of Nardostachys chinensis, a plant of the Nardostachys genus in the Valerianaceae family. In recent years, with the continuous advancement of pharmacological research, scholars have discovered that nardosinone exhibits extensive pharmacological activities. It not only exerts anti-rheumatoid arthritis and anti-tumor effects, but also shows promising application potential in multiple aspects such as anti-arrhythmia, alleviating depressive symptoms, and protecting cardiomyocytes. To systematically summarize the current research status of nardosinone, this paper reviews the research progress on its pharmacological effects and underlying mechanisms, aiming to provide a theoretical basis for further research and drug development of nardosinone.