肺炎支原体对16元大环内酯类药物的敏感性及耐药风险研究进展
Research Progress on the Susceptibility and Resistance Risk of Mycoplasma pneumoniae to 16-Membered Macrolides
摘要: 肺炎支原体(Mycoplasma pneumoniae, MP)是儿童和青壮年社区获得性呼吸道感染的常见病原体。大环内酯类和相关抗生素是治疗这些感染的首选药物，然而大环内酯类药物在肺炎支原体中的耐药率一直在大幅上升。在MP耐药机制相关研究中，23S rRNA V区中A2063G和A2064G基因突变位点对14和15元大环内酯类抗生素具有较高的耐药性，目前尚缺乏系统归纳MP对16元大环内酯类耐药机制研究进展的相关文献报道，本文综述了MP对16元大环内酯类抗生素的耐药机制的研究进展。
Abstract: Mycoplasma pneumoniae (MP) is a common pathogen causing community-acquired respiratory tract infections in children and young adults. Macrolides and related antibiotics are the first-line drugs for treating these infections; however, the resistance rate of MP to macrolides has been increasing substantially. In studies on the resistance mechanisms of MP, the A2063G and A2064G mutations in domain V of the 23S rRNA gene confer high-level resistance to 14- and 15-membered macrolides. Currently, there is a lack of systematic reviews summarizing the research progress on the resistance mechanisms of MP to 16-membered macrolides. This article reviews the advances in understanding the resistance mechanisms of MP to 16-membered macrolide antibiotics.
文章引用：谢华宇, 张刘苗, 张鸿. 肺炎支原体对16元大环内酯类药物的敏感性及耐药风险研究进展[J]. 临床医学进展, 2026, 16(5): 3209-3220. https://doi.org/10.12677/acm.2026.1652140

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