针灸改善慢性肾炎微炎症状态的研究进展

Research Progress on Acupuncture for Microinflammatory State in Chronic Glomerulonephritis

摘要: 慢性肾小球肾炎(CGN)是慢性肾脏病(CKD)的重要病因之一，微炎症状态作为其持续进展的关键病理环节，日益受到临床关注。针灸疗法在改善慢性肾炎患者临床症状、延缓肾功能恶化方面显示出独特优势。本文系统综述了慢性肾炎微炎症状态的病理特征、主要炎症介质及临床意义，梳理了近年来针灸治疗慢性肾炎的临床研究进展，并从调节免疫炎症反应、改善肾脏微循环、调控神经–内分泌–免疫网络及抗氧化应激等多维度探讨针灸干预微炎症状态的可能机制，旨在为针灸辅助治疗慢性肾炎提供理论依据和临床参考。

Abstract: Chronic glomerulonephritis (CGN) is one of the important causes of chronic kidney disease (CKD). Microinflammatory state, as a key pathological link in its continuous progression, has attracted increasing clinical attention. Acupuncture and moxibustion therapy has shown unique advantages in improving clinical symptoms and delaying renal function deterioration in chronic nephritis patients. This paper systematically reviewed the pathological characteristics, main inflammatory mediators and clinical significance of microinflammatory state in chronic glomerulonephritis, summarized the recent clinical research progress of acupuncture in treating chronic nephritis, and explored the possible mechanisms of acupuncture intervention in microinflammatory state from multiple dimensions including regulating immune-inflammatory response, improving renal microcirculation, regulating neuro-endocrine-immune network and anti-oxidative stress, aiming to provide theoretical basis and clinical reference for acupuncture-assisted treatment of chronic glomerulonephritis.