临床使用静电纺丝敷料的有效性与 安全性系统评价
Efficacy and Safety of Electrospun Dressings in Clinical Practice: A Systematic Review
DOI: 10.12677/acm.2026.1652156, PDF,   
作者: 李珊莹*：草本金方健康科技(广东)有限公司，广东 珠海；杨 驰*：西安电子科技大学经济与管理学院，陕西 西安；张仰婷：中山大学附属第七医院科研管理部，广东 深圳；李亚洁：草本金方健康科技(广东)有限公司，广东 珠海；珠海横琴铂华医学检验有限公司，广东 珠海；珠海原妙医学科技股份有限公司，广东 珠海；王剑金：珠海原妙医学科技股份有限公司，广东 珠海；暨南大学生命科学技术学院，广东 广州；梁子欣：中山大学附属第七医院临床研究中心，广东 深圳；康旭明, 师文瀚：中山大学医学院，广东 深圳；杨 曼：中山大学附属第七医院消化医学中心消化内科，广东 深圳；夏 斌, 袁金秋#：中山大学附属第七医院临床研究中心，广东 深圳；中山大学附属第七医院流行病学与生物统计学系，临床大数据研究中心，广东 深圳；孟文勃：兰州大学第一临床医学院普通外科，甘肃 兰州
关键词: 静电纺丝；传统敷料；临床试验；动物实验；Electrospinning； Traditional Dressings； Clinical Trials； Animal Experiments
摘要: 目的：系统评价静电纺丝技术在临床使用中的生物安全性和有效性。方法：计算机检索中国知网(CNKI)、维普中文科技期刊库(VIP)、万方数据知识服务平台、PubMed和Web of science公开发表的文献，搜集关于静电纺丝技术在人群或动物中的使用，检索时限为建库至2025年2月15日。结果：最终纳入文献38篇。2篇文献涉及临床研究，均为中文文献，其余36篇均为动物实验。因纳入临床研究数量较少，且动物实验在种类、伤口模型、干预材料及结局指标测量点上存在高度异质性，无法进行Meta分析合并效应量，故对其进行系统综述。结论：现有证据表明，静电纺丝敷料在动物模型中具有良好的生物安全性和有效性，其疗效普遍优于传统敷料。但相关的临床研究证据较少，未来需要更多大样本的临床试验来验证其临床转化与应用效果。
Abstract: Objective: To systematically evaluate the biosafety and effectiveness of electrospinning technology in vivo. Methods: Computer retrieval of literature published in China National Knowledge Infrastructure (CNKI), VIP Chinese Science and Technology Journal Database, Wanfang Data Knowledge Service Platform, PubMed, and Web of Science, collecting information on the use of electrospinning technology in humans or animals, with a search period from the database establishment to February 15, 2025. Results: A total of 38 articles were included. Among them, 2 articles involved clinical studies, both in Chinese, while the remaining 36 were animal experiments. Due to the limited number of included clinical studies and the substantial heterogeneity observed in animal species, wound models, intervention materials, and outcome measurement points among the animal experiments, it was not feasible to conduct a meta-analysis to pool effect sizes. Consequently, a systematic review was performed. Conclusion: Current evidence indicates that electrospun fiber dressings demonstrate favorable biosafety and efficacy in animal models, with their therapeutic effects generally superior to those of traditional dressings. However, clinical evidence remains limited, necessitating further large-scale clinical trials to validate their potential for clinical translation and application.
文章引用：李珊莹, 杨驰, 张仰婷, 李亚洁, 王剑金, 梁子欣, 康旭明, 师文瀚, 杨曼, 夏斌, 孟文勃, 袁金秋. 临床使用静电纺丝敷料的有效性与 安全性系统评价[J]. 临床医学进展, 2026, 16(5): 3351-3362. https://doi.org/10.12677/acm.2026.1652156

参考文献

[1] Thiruvoth, F., Mohapatra, D., Sivakumar, D., Chittoria, R. and Nandhagopal, V. (2015) Current Concepts in the Physiology of Adult Wound Healing. Plastic and Aesthetic Research, 2, 250-256. [Google Scholar] [CrossRef] 
[2] Haik, J., Kornhaber, R., Blal, B. and Harats, M. (2017) The Feasibility of a Handheld Electrospinning Device for the Application of Nanofibrous Wound Dressings. Advances in Wound Care, 6, 166-174. [Google Scholar] [CrossRef] [PubMed]
[3] Yan, X., Yu, M., Ramakrishna, S., Russell, S.J. and Long, Y. (2019) Advances in Portable Electrospinning Devices for in Situ Delivery of Personalized WOUND Care. Nanoscale, 11, 19166-19178. [Google Scholar] [CrossRef] [PubMed]
[4] Mohamadinooripoor, R., Kashanian, S. and Arkan, E. (2023) An Overview on Wound Dressings and Sutures Fabricated by Electrospinning. Biotechnology and Bioprocess Engineering, 28, 17-35. [Google Scholar] [CrossRef] 
[5] 陈洪让, 沈云, 张海涛, 等. 仿生聚乳酸/明胶纳米纤维膜修复下肢静脉曲张溃疡[J]. 中国组织工程研究, 2019, 23(26): 4217-4224.
[6] 李蠡, 高歌, 张丽, 等. 碳纳米纤维纺丝抗菌敷料制备及实际应用效果比较[J]. 粘接, 2023, 50(7): 73-76.
[7] Wang, L., Huang, T., Xu, X., Bu, N., Wu, Z., Zhao, Y., et al. (2024) Robust Dual Equivariant Gradient Antibacterial Wound Dressing-Loaded Artificial Skin with Nano-Chitin Particles via an Electrospinning-Reactive Strategy. Advanced Fiber Materials, 7, 204-218. [Google Scholar] [CrossRef] 
[8] Ji, X., Li, R., Jia, W., Liu, G., Luo, Y. and Cheng, Z. (2020) Co-Axial Fibers with Janus-Structured Sheaths by Electrospinning Release Corn Peptides for Wound Healing. ACS Applied Bio Materials, 3, 6430-6438. [Google Scholar] [CrossRef] [PubMed]
[9] Gao, Z., Liu, S., Li, S., Shao, X., Zhang, P. and Yao, Q. (2023) Fabrication and Properties of the Multifunctional Rapid Wound Healing Panax Notoginseng@Ag Electrospun Fiber Membrane. Molecules, 28, Article 2972. [Google Scholar] [CrossRef] [PubMed]
[10] Dong, R., Jia, Y., Qin, C., Zhan, L., Yan, X., Cui, L., et al. (2016) In Situ Deposition of a Personalized Nanofibrous Dressing via a Handy Electrospinning Device for Skin Wound Care. Nanoscale, 8, 3482-3488. [Google Scholar] [CrossRef] [PubMed]
[11] 吴忠隐, 朱雅亭, 于建, 等. 可溶性鸡蛋壳膜蛋白-聚丁二酸丁二醇酯共同静电纺丝负载凝血酶制备新型止血敷料的可行性研究[J]. 中国血管外科杂志(电子版), 2021, 13(1): 54-60.
[12] Dong, R., Li, Y., Chen, M., Xiao, P., Wu, Y., Zhou, K., et al. (2022) In Situ Electrospinning of Aggregation‐Induced Emission Nanofibrous Dressing for Wound Healing. Small Methods, 6, Article ID: 2101247. [Google Scholar] [CrossRef] [PubMed]
[13] Yu, B., He, C., Wang, W., Ren, Y., Yang, J., Guo, S., et al. (2020) Asymmetric Wettable Composite Wound Dressing Prepared by Electrospinning with Bioinspired Micropatterning Enhances Diabetic Wound Healing. ACS Applied Bio Materials, 3, 5383-5394. [Google Scholar] [CrossRef] [PubMed]
[14] Yin, L., Tang, Q., Ke, Q., Zhang, X., Su, J., Zhong, H., et al. (2023) Sequential Anti-Infection and Proangiogenesis of DMOG@ZIF-8/Gelatin-PCL Electrospinning Dressing for Chronic Wound Healing. ACS Applied Materials & Interfaces, 15, 48903-48912. [Google Scholar] [CrossRef] [PubMed]
[15] Jiang, F., Li, X., Duan, Y., Li, Q., Qu, Y., Zhong, G., et al. (2023) Extraction and Characterization of Chitosan from Eupolyphaga sinensis Walker and Its Application in the Preparation of Electrospinning Nanofiber Membranes. Colloids and Surfaces B: Biointerfaces, 222, Article ID: 113030. [Google Scholar] [CrossRef] [PubMed]
[16] Pal, P., Dadhich, P., Srivas, P.K., Das, B., Maulik, D. and Dhara, S. (2017) Bilayered Nanofibrous 3D Hierarchy as Skin Rudiment by Emulsion Electrospinning for Burn Wound Management. Biomaterials Science, 5, 1786-1799. [Google Scholar] [CrossRef] [PubMed]
[17] Coman, C., Anisiei, A., Cibotaru, S., Ailincai, D., Pasca, S.A., Chabot, C., et al. (2024) Chitosan-Electrospun Fibers Encapsulating Norfloxacin: The Impact on the Biochemical, Oxidative and Immunological Profile in a Rats Burn Model. International Journal of Molecular Sciences, 25, Article 12709. [Google Scholar] [CrossRef] [PubMed]
[18] Zhao, H., Xu, Y., Wang, S., Li, P., Wang, T., Zhang, F., et al. (2022) “Jianbing” Styling Multifunctional Electrospinning Composite Membranes for Wound Healing. Frontiers in Bioengineering and Biotechnology, 10, Article 943695. [Google Scholar] [CrossRef] [PubMed]
[19] 陈华, 刘宁, 沙娜, 等. 静电纺丝素纳米纤维对大鼠深Ⅱ度烧伤创面愈合的作用[J]. 华中科技大学学报(医学版), 2021, 50(2): 180-184.
[20] 刘宁, 陈华, 刘海华, 等. 纳米丝素纤维敷料促进大鼠深度烧伤创面愈合的研究[J]. 中外医疗, 2020, 39(23): 45-47.
[21] 陈洪让, 张海涛, 邓坤学, 等. 手持静电纺丝可降解纳米纤维原位修复全层皮肤缺损[J]. 中国组织工程研究, 2019, 23(2): 257-264.
[22] Cui, Y., Huang, Z., Lei, L., Li, Q., Jiang, J., Zeng, Q., et al. (2021) Robust Hemostatic Bandages Based on Nanoclay Electrospun Membranes. Nature Communications, 12, Article No. 5922. [Google Scholar] [CrossRef] [PubMed]
[23] Liao, J., Zhong, S., Wang, S., Liu, J., Chen, J., He, G., et al. (2017) Preparation and Properties of a Novel Carbon Nanotubes/Poly(Vinyl Alcohol)/Epidermal Growth Factor Composite Biological Dressing. Experimental and Therapeutic Medicine, 14, 2341-2348. [Google Scholar] [CrossRef] [PubMed]
[24] Lu, L., Fu, R., Li, C., Yu, C., Li, Z., Guan, H., et al. (2013) Silver Nanoparticle/Chitosan Oligosaccharide/Poly(Vinyl Alcohol) Nanofibers as Wound Dressings: A Preclinical Study. International Journal of Nanomedicine, 8, 4131-4145. [Google Scholar] [CrossRef] [PubMed]
[25] Rho, K.S., Jeong, L., Lee, G., Seo, B., Park, Y.J., Hong, S., et al. (2006) Electrospinning of Collagen Nanofibers: Effects on the Behavior of Normal Human Keratinocytes and Early-Stage Wound Healing. Biomaterials, 27, 1452-1461. [Google Scholar] [CrossRef] [PubMed]
[26] 何香, 王晶, 邢梓鑫, 等. 载吲哚美辛纳米纤维的制备及其促伤口愈合性能[J]. 应用化学, 2024, 41(11): 1629-1638.
[27] Liu, T., Xie, F., Geng, L., He, R., Sun, M., Ni, T., et al. (2025) Micro-Electro Nanofibrous Dressings Based on PVDF-AgNPs as Wound Healing Materials to Promote Healing in Active Areas. International Journal of Nanomedicine, 20, 771-789. [Google Scholar] [CrossRef] [PubMed]
[28] 雷凯君, 强润润, 李怀国, 等. 伤科黄水/聚乙烯醇静电纺丝纳米纤维创面敷料的制备及其性能[J]. 应用化学, 2023, 40(11): 1539-1549.
[29] 吕元菊, 吴文丽, 刘泽梅, 等. 头花蓼纳米纤维功能敷料的药效评价[J]. 中国药房, 2023, 34(20): 2507-2512.
[30] Chen, K., Pan, H., Ji, D., Li, Y., Duan, H. and Pan, W. (2021) Curcumin-Loaded Sandwich-Like Nanofibrous Membrane Prepared by Electrospinning Technology as Wound Dressing for Accelerate Wound Healing. Materials Science and Engineering: C, 127, Article ID: 112245. [Google Scholar] [CrossRef] [PubMed]
[31] AlMotawa, R.Y., Alhamid, G., Badran, M.M., Orfali, R., Alomrani, A.H., Tawfik, E.A., et al. (2024) Co-Delivery of Dragon’s Blood and Alkanna Tinctoria Extracts Using Electrospun Nanofibers: In Vitro and in Vivo Wound Healing Evaluation in Diabetic Rat Model. Pharmaceutics, 16, Article 704. [Google Scholar] [CrossRef] [PubMed]
[32] Zhao, L., Chen, D., Yao, Q. and Li, M. (2017) Studies on the Use of Recombinant Spider Silk Protein/Polyvinyl Alcohol Electrospinning Membrane as Wound Dressing. International Journal of Nanomedicine, 12, 8103-8114. [Google Scholar] [CrossRef] [PubMed]
[33] 刘丽萍, 李驰宇, 杨韬, 等. PTMC/PVP温控收缩性纳米纤维膜与小鼠成纤维细胞的生物相容性及其对大鼠皮肤全层缺损的修复作用[J]. 吉林大学学报(医学版), 2024, 50(4): 939-946.
[34] Li, J., Meng, H., Guo, W., Zhou, L., Wu, S., Gao, G., et al. (2025) In-Situ Electrospinning Dressings Loaded with Kaempferol for Reducing MMP9 to Promote Diabetic Ulcer Healing. International Journal of Nanomedicine, 20, 1101-1117. [Google Scholar] [CrossRef] [PubMed]
[35] Li, J., Chen, J., Peng, Z., Chen, N., Liu, C., Zhang, P., et al. (2022) Multifunctional Electrospinning Polyhydroxyalkanoate Fibrous Scaffolds with Antibacterial and Angiogenesis Effects for Accelerating Wound Healing. ACS Applied Materials & Interfaces, 15, 364-377. [Google Scholar] [CrossRef] [PubMed]
[36] Bao, X., Zhu, Q., Chen, Y., Tang, H., Deng, W., Guo, H., et al. (2022) Antibacterial and Antioxidant Films Based on HA/Gr/TA Fabricated Using Electrospinning for Wound Healing. International Journal of Pharmaceutics, 626, Article ID: 122139. [Google Scholar] [CrossRef] [PubMed]
[37] Park, W.H., Jeong, L., Kim, M.H., Jung, J. and Min, B.M. (2014) Effect of Silk Fibroin Nanofibers Containing Silver Sulfadiazine on Wound Healing. International Journal of Nanomedicine, 9, 5277-5287. [Google Scholar] [CrossRef] [PubMed]
[38] Wang, J., Zhao, T., Liu, Z., Dong, X., Zhang, W., Wang, T., et al. (2025) In-Situ Electrospinning Technology Driving Composite System with Enhanced Adhesive Property and Biodegradability for Noncompressible Hemostasis and Anti-Inflammatory. Applied Materials Today, 42, Article ID: 102552. [Google Scholar] [CrossRef] 
[39] Stojko, M., Włodarczyk, J., Sobota, M., Karpeta-Jarząbek, P., Pastusiak, M., Janeczek, H., et al. (2020) Biodegradable Electrospun Nonwovens Releasing Propolis as a Promising Dressing Material for Burn Wound Treatment. Pharmaceutics, 12, Article 883. [Google Scholar] [CrossRef] [PubMed]

为你推荐