近五年针灸伴中药治疗对创伤后应激障碍作用研究

Effects of Acupuncture with Chinese Herbal Medicine on Post-Traumatic Stress Disorder: A Review of Research from the Past Five Years

摘要: 临床研究揭示，针灸能够显著缓解创伤后应激障碍(PTSD)所带来的种种困扰。其原因在于它巧妙地干预了神经回路的运作、调整了神经递质与受体的平衡、影响了信号传递的路径、调控了细胞凋亡的过程、改变了免疫因子的活跃程度，以及调动了内源性大麻素系统——正是通过这些精妙的调节，针灸成为了对抗PTSD的有效利器。与此同时，中药凭借其多靶点、多组分、多路径的独特优势，在PTSD的治疗领域同样绽放异彩。诸多草药方剂不仅能够纠正PTSD模型动物身上的异常行为，还能逆转一系列神经生物学的异常指标。本文拟从治疗机理与临床疗效两个维度，对这些发现进行系统梳理与阐述。

Abstract: According to clinical studies, acupuncture is capable of significantly easing the complex symptoms tied to post-traumatic stress disorder (PTSD). This therapeutic effect is attributed to its intricate modulation of neural circuit function, rebalancing of neurotransmitters and their receptors, regulation of signaling pathways, control of apoptotic processes, alteration of immune factor activity, and engagement of the endocannabinoid system. Through these sophisticated regulatory mechanisms, acupuncture serves as an effective intervention against PTSD. Concurrently, Chinese herbal medicine, leveraging its unique advantages of multi-target, multi-component, and multi-pathway actions, has also demonstrated remarkable promise in the treatment of PTSD. Numerous herbal formulas not only correct aberrant behaviors in PTSD animal models but also reverse a range of neurobiological abnormalities. This article aims to systematically review and elucidate these findings from the perspectives of therapeutic mechanisms and clinical efficacy.