基于网络毒理学与分子对接探究环境内分泌干扰物诱导骨质疏松症的机制
Exploring the Mechanism of Environmental Endocrine Disruptor-Induced Osteoporosis Based on Network Toxicology and Molecular Docking
DOI: 10.12677/hjbm.2026.163056, PDF,   
作者: 毕松兰：云南省大理市洱源县人民医院老年医学科，云南 大理
关键词: 内分泌干扰物；网络毒理学；分子对接；骨质疏松症；Endocrine Disruptors； Network Toxicology； Molecular Docking； Osteoporosis
摘要: 目的：内分泌干扰物作为一类新型污染物，本研究旨在探讨其诱导骨质疏松症的潜在机制。方法：采用网络毒理学与分子对接技术，阐明内分泌干扰物诱发骨质疏松症的分子机制。借助PubChem、ChEMBL、Super-PRED、GeneCards、OMIM、TTD等数据库，筛选与内分泌干扰物及骨质疏松症相关的潜在靶点；通过STRING分析与Cytoscape软件确定与骨质疏松症显著关联的核心靶点；利用DAVID数据库对核心靶点进行GO功能与KEGG通路富集分析；最后通过分子对接验证内分泌干扰物与核心靶蛋白的结合能力。结果：内分泌干扰物可能通过调控细胞表达、影响细胞凋亡与增殖、调控相关信号通路等途径诱发骨质疏松症。结论：本研究为阐明内分泌干扰物诱发骨质疏松症的机制提供了新思路，为骨质疏松症的预防与治疗策略提供了理论依据。
Abstract: Objective: Endocrine disruptors are a new type of pollutant. This paper aims to explore their potential mechanisms in inducing osteoporosis. Method: Network toxicology and molecular docking techniques were used to elucidate the molecular mechanism of endocrine disruptor-induced osteoporosis. Using databases such as PubChem, ChEMBL, Super-PRED, GeneCards, OMIM, TTD, etc., potential targets related to endocrine disruptors and osteoporosis were screened; the core targets significantly associated with osteoporosis through STRING analysis and Cytoscape software were determined; GO functional and KEGG pathway enrichment analysis on core targets using the DAVID database were performed; finally, the binding ability of endocrine disruptors to core target proteins was verified through molecular docking. Result: Endocrine disruptors may induce osteoporosis by regulating cell expression, affecting cell apoptosis and proliferation, and regulating related signaling pathways. Conclusion: This study provides a new idea for elucidating the mechanism of endocrine disruptors inducing osteoporosis, and provides a theoretical basis for the prevention and treatment strategies of osteoporosis.
文章引用：毕松兰. 基于网络毒理学与分子对接探究环境内分泌干扰物诱导骨质疏松症的机制[J]. 生物医学, 2026, 16(3): 539-548. https://doi.org/10.12677/hjbm.2026.163056

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