经颅多普勒发泡试验对隐源性卒中以及偏头痛合并卵圆孔未闭的筛查价值
The Value of Cranial Doppler Foam Test in Screening for Cryptogenic Stroke and Migraine with Patent Foramen Ovale
DOI: 10.12677/acm.2026.1662203, PDF,    科研立项经费支持
作者: 吴仙红, 杨 莹, 潘公华：玉环市第二人民医院神经内科，浙江 玉环
关键词: 经颅多普勒发泡试验；隐源性卒中；偏头痛；卵圆孔未闭；Transcranial Doppler Foam Test； Cryptogenic Stroke； Migraine； Patent Foramen Ovale
摘要: 目的：评估经颅多普勒发泡试验(c-TCD)在卵圆孔未闭(PFO)相关隐源性卒中及偏头痛患者中的临床应用价值。方法：采用回顾性队列研究设计，纳入2023年12月至2025年12月期间确诊的112例隐源性卒中患者和169例偏头痛患者作为研究对象，通过Valsalva动作诱导后联合实施c-TCD与经食管超声心动图(TEE)右心声学造影，对比分析两种检测技术对PFO的检测效率。结果：c-TCD对PFO并隐源性脑卒中的检出率为34.82% (39/112)，而TEE合并右心声学造影的检出率为41.07% (46/112)，差异无统计学意义(χ2 = 0.929, P = 0.335) c-TCD对PFO并偏头痛的检出率为52.67% (59/169)，而TEE合并右心声学造影的检出率为38.46% (65/112)，差异无统计学意义(χ2 = 0.459, P = 0.498)。c-TCD与右心声学造影对PFO右向左分流半定量分级的比较无显著性差异(χ2 = 4.092, P = 0.252)。结论：Valsalva动作激发后，c-TCD对隐源性脑卒中以及偏头痛并PFO的检测效率与TEE合并右心声学造影检查检测效率无显著性差异，其具有较高的临床诊断价值。
Abstract: Objective: To evaluate the clinical application value of transcranial Doppler foam test (c-TCD) in patients with patent foramen ovale (PFO)-related cryptogenic stroke and migraine. Method: A retrospective cohort study design was adopted. 112 patients with cryptogenic stroke and 169 patients with migraine diagnosed from December 2023 to December 2025 were included as the research subjects. After Valsalva maneuver, c-TCD and transesophageal echocardiography (TEE) right heart acoustic contrast were jointly implemented to compare and analyze the detection efficiency of the two detection techniques for PFO. Results: The detection rate of PFO and cryptogenic stroke by c-TCD was 34.82% (39/112), while the detection rate of PFO and cryptogenic stroke by TEE combined with right heart acoustic contrast was 41.07% (46/112), with no statistically significant difference (χ2 = 0.929, P = 0.335). The detection rate of PFO and migraine by c-TCD was 52.67% (59/169), while the detection rate of PFO and migraine by TEE combined with right heart acoustic contrast was 38.46% (65/112), with no statistically significant difference (χ2 = 0.459, P = 0.498). There was no significant difference in the semi-quantitative grading of right-to-left shunt of PFO between c-TCD and right heart acoustic contrast (χ2 = 4.092, P = 0.252). Conclusion: After Valsalva maneuver, the detection efficiency of c-TCD for cryptogenic stroke and PFO-related migraine is not significantly different from that of TEE combined with right heart acoustic contrast, and it has a high clinical diagnostic value.
文章引用：吴仙红, 杨莹, 潘公华. 经颅多普勒发泡试验对隐源性卒中以及偏头痛合并卵圆孔未闭的筛查价值[J]. 临床医学进展, 2026, 16(6): 140-145. https://doi.org/10.12677/acm.2026.1662203

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