表观遗传学在肠易激综合征发病机制中的研究进展
Research Progress on Epigenetics in Pathogenesis of Irritable Bowel Syndrome
DOI: 10.12677/acm.2026.1662216, PDF,    科研立项经费支持
作者: 钱仲秋：长兴县中医院吕山分院中医内科，浙江 湖州；王颖颖*：长兴县中医院脾胃病科，浙江 湖州
关键词: 肠易激综合征；表观遗传学；组蛋白去乙酰化酶(HDAC)；微小RNA；Irritable Bowel Syndrome (IBS)； Epigenetics； Histone Deacetylase (HDAC)； microRNA (miRNA)
摘要: 肠易激综合征(irritable bowel syndrome, IBS)发病机制复杂，目前尚未被完全阐明。近年来研究表明表观遗传学在IBS病理生理学中发挥重要作用，其包括DNA甲基化、组蛋白修饰、非编码RNA、染色质重塑。表观遗传学未来可能应用于IBS的诊断和治疗。本文就肠屏障功能、肠道炎症及免疫、肠道菌群、脑肠轴及内脏超敏反应、神经递质传导五方面论述表观遗传学在IBS病理生理学中的研究新进展。
Abstract: The pathogenesis of irritable bowel syndrome (IBS) is complex and has not been fully elucidated. In recent years, studies have shown that epigenetics plays an important role in the pathophysiology of IBS, including DNA methylation, histone modification, non-coding RNA, and chromatin remodeling. Epigenetics may be applied to the diagnosis and treatment of IBS in the future. This article reviews the latest research advances in the role of epigenetics in the pathophysiology of IBS from five aspects: intestinal barrier function, intestinal inflammation and immunity, gut microbiota, gut-brain axis and visceral hypersensitivity, and neurotransmitter transmission.
文章引用：钱仲秋, 王颖颖. 表观遗传学在肠易激综合征发病机制中的研究进展[J]. 临床医学进展, 2026, 16(6): 260-267. https://doi.org/10.12677/acm.2026.1662216

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