乳腺癌化疗相关认知障碍早期识别及预防的 研究进展
Research Progress in Early Identification and Prevention of Cognitive Impairment Associated with Chemotherapy for Breast Cancer
DOI: 10.12677/acm.2026.1662218, PDF,    科研立项经费支持
作者: 高 杰, 袁娴雅, 郭桂月, 范振崴*：北华大学护理学院，吉林 吉林
关键词: 乳腺肿瘤；化疗；认知障碍；护理；综述；Breast Cancer； Chemotherapy； Cognitive Impairment； Nurse； Review
摘要: 癌症相关认知障碍是接受化疗的乳腺癌患者抑郁的首要原因，不仅在一定程度上限制了患者的日常活动，甚至威胁生命。癌症相关认知障碍的早期识别及预防对患者的生存受益，转变负性结局。该文深入探讨了乳腺癌化疗相关认知障碍的危险因素、发病机制及预防措施。旨在揭示其复杂机制，为临床医生提供诊断依据和个性化的治疗方案。从而提高患者的生存质量，为临床实践提供理论支撑和实证依据。
Abstract: Cancer-related cognitive impairment is the leading cause of depression in breast cancer patients undergoing chemotherapy, which not only limits daily activities to some extent, but even threatens life. Early identification of cancer-related cognitive impairment and preventive measures can improve patients’ survival outcomes and transform negative outcomes. This article provides an in-depth systematic review of the risk factors, pathogenesis and preventive measures of chemotherapy-related cognitive impairment in breast cancer. It aims to reveal the complex mechanisms and provide clinicians with diagnostic basis and personalized treatment plans. This will improve the quality of patients’ survival and provide theoretical support and empirical evidence for clinical practice.
文章引用：高杰, 袁娴雅, 郭桂月, 范振崴. 乳腺癌化疗相关认知障碍早期识别及预防的 研究进展[J]. 临床医学进展, 2026, 16(6): 276-280. https://doi.org/10.12677/acm.2026.1662218

参考文献

[1] Siegel, R.L., Kratzer, T.B., Giaquinto, A.N., Sung, H. and Jemal, A. (2025) Cancer Statistics, 2025. CA: A Cancer Journal for Clinicians, 75, 10-45. [Google Scholar] [CrossRef] [PubMed]
[2] Hangcheng, X. and Binghe, X. (2025) Epidemiology, Early Detection, and Management of Breast Cancer in China: A Comprehensive Review. Chinese Journal of Cancer Research, 37, 882-899. [Google Scholar] [CrossRef] 
[3] Janelsins, M.C. and Magnuson, A. (2026) Unraveling the Complexity of Cancer-Related Cognitive Impairment in Breast Cancer—Effect of Differing Treatments and Menopausal Status. JAMA Oncology, 12, 146-148. [Google Scholar] [CrossRef] 
[4] 陈静, 查梦培, 王亚非. 癌症患者相关认知障碍的研究进展[J]. 天津护理, 2025, 33(3): 368-372.
[5] Huberts, A.S., Albers, E.A.C., de Ligt, K.M., Koppert, L.B., Schagen, S.B. and van de Poll-Franse, L.V. (2024) Self-perceived Cognitive Impairment in the First Year after Breast Cancer and the Identification of At-Risk Patients. European Journal of Oncology Nursing, 72, Article ID: 102685. [Google Scholar] [CrossRef] [PubMed]
[6] Jung, W.H., Chun, M. and Kim, N.H. (2025) Changes in Cognitive Function and Functional Brain Networks in Chemotherapy-Exposed Patients with Breast Cancer: A Longitudinal Study. Neuroscience, 577, 1-9. [Google Scholar] [CrossRef] [PubMed]
[7] Hodgson, K.D., Hutchinson, A.D., Wilson, C.J. and Nettelbeck, T. (2013) A Meta-Analysis of the Effects of Chemotherapy on Cognition in Patients with Cancer. Cancer Treatment Reviews, 39, 297-304. [Google Scholar] [CrossRef] [PubMed]
[8] Sanft, T., Day, A.T., Ansbaugh, S.M., et al. (2025) NCCN Guidelines® Insights: Survivorship, Version 2.2025: Featured Updates to the NCCN Guidelines®. Journal of the National Comprehensive Cancer Network, 23, 208-217.
[9] Zhang, T.H., Chen, X., Wei, Y.Y., Tang, X.C., Xu, L.H., Cui, H.R., et al. (2025) Associations between Cytokine Levels and Cognitive Function among Individuals at Clinical High Risk for Psychosis. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 136, Article ID: 111166. [Google Scholar] [CrossRef] [PubMed]
[10] Zhou, Z., Ren, J., Liu, Q., Li, S., Xu, J., Wu, X., et al. (2024) A Nomogram for Predicting the Risk of Cancer-Related Cognitive Impairment in Breast Cancer Patients Based on a Scientific Symptom Model. Scientific Reports, 14, Article No. 14566. [Google Scholar] [CrossRef] [PubMed]
[11] Liu, Y., Li, R., Chen, L., Zhao, F., Su, Y., Jin, S., et al. (2025) Construction and Validation of a Risk-Prediction Model for Chemotherapy-Related Cognitive Impairment in Patients with Breast Cancer. Journal of Cancer Survivorship, 19, 1483-1495. [Google Scholar] [CrossRef] [PubMed]
[12] Shaw, E.G., Rosdhal, R., D’Agostino, R.B., Lovato, J., Naughton, M.J., Robbins, M.E., et al. (2006) Phase II Study of Donepezil in Irradiated Brain Tumor Patients: Effect on Cognitive Function, Mood, and Quality of Life. Journal of Clinical Oncology, 24, 1415-1420. [Google Scholar] [CrossRef] [PubMed]
[13] Rapp, S.R., Dressler, E.V., Brown, W.M., Wade, J.L., Le-Lindqwister, N., King, D., et al. (2024) Phase III Randomized, Placebo-Controlled Clinical Trial of Donepezil for Treatment of Cognitive Impairment in Breast Cancer Survivors after Adjuvant Chemotherapy (WF-97116). Journal of Clinical Oncology, 42, 2546-2557. [Google Scholar] [CrossRef] [PubMed]
[14] Lengacher, C.A., Reich, R.R., Rodriguez, C.S., Nguyen, A.T., Park, J.Y., Meng, H., et al. (2025) Efficacy of Mindfulness-Based Stress Reduction for Breast Cancer (MBSR(BC)) a Treatment for Cancer-Related Cognitive Impairment (CRCI): A Randomized Controlled Trial. Journal of Integrative and Complementary Medicine, 31, 75-91. [Google Scholar] [CrossRef] [PubMed]
[15] Garland, S.N., Tulk, J., Savard, J., Rash, J.A., Browne, S., Urquhart, R., et al. (2024) Randomized Controlled Trial of Virtually Delivered Cognitive Behavioral Therapy for Insomnia to Address Perceived Cancer-Related Cognitive Impairment in Cancer Survivors. Journal of Clinical Oncology, 42, 2094-2104. [Google Scholar] [CrossRef] [PubMed]

为你推荐