白细胞介素-6在儿童重症创伤早期监测中的意义及临床应用进展
Significance and Research Progress of Interleukin-6 in Early Monitoring of Severe Pediatric Trauma
摘要: 儿童群体创伤暴露风险显著高于成人，重症创伤患儿病情进展迅速且复杂，是导致儿童死亡和长期残疾的主要原因之一。在重症创伤患儿的管理中，早期准确评估对改善预后至关重要。白细胞介素-6 (interleukin-6, IL-6)是一种典型多功能细胞因子，可用于儿童重症创伤严重程度早期评估、脓毒症/MODS风险预警、脓毒症辅助诊断及预后判断，但不能单独作为确诊依据。监测IL-6水平有助于评估儿童重症创伤严重程度，其通路抑制剂具有潜在治疗价值。
Abstract: Children have a significantly higher risk of trauma exposure than adults. Children with severe trauma present rapid and complex disease progression, which constitutes one of the leading causes of pediatric death and long-term disability. Early and accurate assessment is essential for optimizing the prognosis in the clinical management of children with severe trauma. Interleukin-6 (IL-6) is a typical multifunctional cytokine. It can be used for the early assessment of injury severity, early warning of sepsis and multiple organ dysfunction syndrome (MODS), auxiliary diagnosis of sepsis, and prognostic evaluation in children with severe trauma, whereas it cannot be used alone as the definitive diagnostic criterion. Monitoring IL-6 levels contributes to evaluating the severity of severe pediatric trauma, and inhibitors targeting its signaling pathway possess potential therapeutic value.
文章引用：徐杰, 杨箬雨, 任帅. 白细胞介素-6在儿童重症创伤早期监测中的意义及临床应用进展[J]. 临床个性化医学, 2026, 5(3): 45-50. https://doi.org/10.12677/jcpm.2026.53182

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