基于“脑肠轴”探讨从脾论治围绝经期抑郁的内涵

Discussion on the Essential Connotation of Spleen-Related Treatment for Perimenopausal Depression Based on the “Intestinal Flora-Gut-Brain” Axis

摘要: 围绝经期抑郁是一种在女性围绝经期常见的精神障碍，严重影响女性的身心健康。神经递质水平、激素波动及炎性因子升高是围绝经期抑郁发生发展的重要因素，有研究表明脑肠轴可以通过以上机制影响围绝经期抑郁。在中医学中，脾主运化，为后天之本，在志为思，藏营舍意，脾虚可能导致情绪障碍。本文从脑肠轴的角度出发，通过分析脾在围绝经期抑郁中的作用机制，整合现代医学对脑肠轴的理解，并深入探讨了中医从脾论治与脑肠轴理论之间的共通点。为中医学治疗围绝经期抑郁提供现代科学内涵，以期达到更好的治疗效果。

Abstract: Perimenopausal depression is a common mental disorder in women during perimenopausal period, which seriously affects women’s physical and mental health. Neurotransmitter levels, hormone fluctuations and elevated inflammatory factors are important factors in the development of perimenopausal depression. Studies have shown that the brain-gut axis can affect perimenopausal depression through the above mechanisms. In traditional Chinese medicine, the spleen governs transportation and transformation, which is the foundation of acquired nature. In the mind, it stores the intention of the camp, and the spleen deficiency may lead to emotional disorders. From the perspective of brain-gut axis, this paper analyzes the mechanism of spleen in perimenopausal depression, integrates the understanding of brain-gut axis in modern medicine, and deeply discusses the common points between traditional Chinese medicine treatment from spleen and brain-gut axis theory. To provide modern scientific connotation for the treatment of perimenopausal depression in traditional Chinese medicine, in order to achieve better therapeutic effect.