细胞互作在动脉粥样硬化发生发展中的作用
The Role of Cellular Interactions in the Initiation and Progression of Atherosclerosis
DOI: 10.12677/jcpm.2026.53188, PDF,   
作者: 刘 莹：济宁医学院临床医学院，山东 济宁；陈雪英, 甘立军*：济宁医学院附属医院心内科，山东 济宁
关键词: 动脉粥样硬化；内皮细胞；平滑肌细胞；巨噬细胞；血小板；Atherosclerosis； Endothelial Cells； Vascular Smooth Muscle Cells； Macrophages； Platelets
摘要: 动脉粥样硬化(Atherosclerosis, AS)是引发心血管疾病的主要原因，具有较高的发病率与死亡率，对全球公共健康构成了严峻挑战。该疾病的发病机制极为复杂，涉及多种类型的细胞，包括内皮细胞、平滑肌细胞、单核/巨噬细胞、血小板等。多种细胞互相作用，在动脉粥样硬化发生发展过程中发挥重要作用。本文系统综述了动脉粥样硬化发展过程中细胞相互作用的机制，旨在为动脉粥样硬化相关疾病的临床预防和治疗提供参考。
Abstract: Atherosclerosis is the primary cause of cardiovascular diseases, characterized by high morbidity and mortality, posing a significant challenge to global public health. The pathogenesis of AS is highly complex, involving multiple cell types, including endothelial cells, smooth muscle cells, monocytes/macrophages and others. The intricate and dynamic interactions among these cells play a crucial role in the progression of atherosclerosis. This review systematically summarizes the mechanisms underlying cell-cell interactions during the development of atherosclerosis, aiming to provide insights for the clinical prevention and treatment of atherosclerosis-related diseases.
文章引用：刘莹, 陈雪英, 甘立军. 细胞互作在动脉粥样硬化发生发展中的作用[J]. 临床个性化医学, 2026, 5(3): 98-105. https://doi.org/10.12677/jcpm.2026.53188

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