植物化合物抗皮肤衰老的分子机制研究进展
Research Progress on the Molecular Mechanism of Plant Compounds in Anti-Skin Aging
DOI: 10.12677/acm.2026.1662261, PDF,    科研立项经费支持
作者: 耿瑞泰, 李文娟*：济宁医学院医学影像与检验学院，山东 济宁
关键词: 植物化合物；皮肤衰老；光老化；基质金属蛋白酶；信号通路；自噬；Plant Compounds； Skin Aging； Photoaging； Matrix Metalloproteinases； Signaling Pathways； Autophagy
摘要: 皮肤衰老是由内在因素与外在因素共同作用的复杂生物学过程，其中紫外线诱导的光老化是导致皮肤结构和功能损害的主要环境因素。植物化合物来源广泛，且具有多靶点作用特性，可通过抗氧化、抗炎、抑制基质金属蛋白酶活性、促进胶原合成、调控自噬与线粒体稳态以及清除衰老细胞等多种机制，延缓皮肤衰老和预防光老化。本文系统综述了近年来植物化合物抗皮肤衰老的分子机制研究进展，重点从氧化应激与炎症调控、基质金属蛋白酶介导的细胞外基质保护、胶原合成与细胞再生、自噬与线粒体稳态调控、细胞衰老调控以及核心信号通路的交叉调控网络等方面进行阐述，以期推动植物化合物从实验室走向应用，为促进皮肤健康老化提供安全有效的天然策略。
Abstract: Skin aging is a complex biological process driven by both intrinsic and extrinsic factors, among which ultraviolet-induced photoaging is the major environmental factor leading to structural and functional damage to the skin. Plant compounds, as natural products with wide sources and multi-target effects, exhibit unique application value in delaying skin aging and preventing photoaging through multiple mechanisms, including anti-oxidation, anti-inflammation, inhibition of matrix metalloproteinases activity, promotion of collagen synthesis, regulation of autophagy and mitochondrial homeostasis, and elimination of senescent cells. This review systematically summarizes recent advances in the molecular mechanisms of plant compounds against skin aging, focusing on the regulation of oxidative stress and inflammation, MMPs-mediated extracellular matrix protection, collagen synthesis and cell regeneration, autophagy and mitochondrial homeostasis regulation, cellular senescence control, and the cross-regulatory network of core signaling pathways. The aim is to promote the translation of phytochemicals from the laboratory to practical applications, thereby providing safe and effective natural strategies for promoting healthy skin aging.
文章引用：耿瑞泰, 李文娟. 植物化合物抗皮肤衰老的分子机制研究进展[J]. 临床医学进展, 2026, 16(6): 637-645. https://doi.org/10.12677/acm.2026.1662261

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