中药活性成分调控细胞焦亡治疗非小细胞肺癌的研究进展
Research Progress on the Use of Bioactive Compounds from Traditional Chinese Medicine to Regulate Pyroptosis for the Treatment of Non-Small Cell Lung Cancer
DOI: 10.12677/acm.2026.1662266, PDF,    科研立项经费支持
作者: 薛倩倩, 潘继普, 寇婉莹, 于龙跃, 陈宜新, 张淑睿：黑龙江中医药大学第二临床医学院，黑龙江 哈尔滨；张家欣：广州中医药大学深圳医院(福田)心血管科，广东 深圳；甘仕虎, 杨善军*：黑龙江中医药大学附属第二医院肺病科，黑龙江 哈尔滨
关键词: 细胞焦亡；中药活性成分；NSCLC；研究进展；Pyroptosis； Active Components in Traditional Chinese Medicine； NSCLC； Research Progress
摘要: 非小细胞肺癌(NSCLC)是肺癌的主要亚型，临床治疗仍存在疗效有限、耐药频发等局限。细胞焦亡是一种促炎性程序性细胞死亡方式，在NSCLC中具有抑癌与促癌双重作用，是重要的潜在治疗靶点。近年来，研究表明，多种中药活性成分可通过调控NLRP3炎症小体、caspase-1/GSDMD及caspase-3/GSDME等信号轴，从激活焦亡直接杀伤肿瘤细胞、抑制炎症性焦亡改善肿瘤微环境以及逆转耐药等方面发挥抗NSCLC作用。本文系统综述中药活性成分调控细胞焦亡抗NSCLC的作用机制及研究现状，以期为中医药靶向细胞焦亡治疗NSCLC提供参考，推动中药活性成分的临床转化与应用。
Abstract: Non-small cell lung cancer (NSCLC) is the main subtype of lung cancer, and clinical treatment still has limitations, such as limited efficacy and frequent drug resistance. Pyroptosis is a pro-inflammatory form of programmed cell death that has both anti-cancer and pro-cancer effects in NSCLC, making it an important potential therapeutic target. Recent studies have shown that various active components of traditional Chinese medicine can exert anti-NSCLC effects by regulating signaling axes such as NLRP3 inflammasome, caspase-1/GSDMD, and caspase-3/GSDME. These components can directly kill tumor cells by activating pyroptosis, inhibit inflammatory pyroptosis to improve the tumor microenvironment, and reverse drug resistance. This article systematically reviews the mechanisms and current research status of traditional Chinese medicine (TCM) active components in regulating pyroptosis to combat NSCLC, aiming to provide a reference for TCM-targeted pyroptosis therapy for NSCLC and to promote the clinical translation and application of TCM active components.
文章引用：薛倩倩, 张家欣, 甘仕虎, 潘继普, 寇婉莹, 于龙跃, 陈宜新, 张淑睿, 杨善军. 中药活性成分调控细胞焦亡治疗非小细胞肺癌的研究进展[J]. 临床医学进展, 2026, 16(6): 683-692. https://doi.org/10.12677/acm.2026.1662266

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