中医药治疗重症肌无力的临床证据与机制研究进展
Progress in Clinical Evidence and Mechanism Research of Traditional Chinese Medicine in the Treatment of Myasthenia Gravis
DOI: 10.12677/tcm.2026.156318, PDF,   
作者: 庄 雨：黑龙江中医药大学研究生院，黑龙江 哈尔滨；程为平*：黑龙江中医药大学附属第一医院针灸二科，黑龙江 哈尔滨
关键词: 中医药；重症肌无力；文献综述；Traditional Chinese Medicine； Myasthenia Gravis； Literature Review
摘要: 重症肌无力是一种由自身抗体介导的、累及神经肌肉接头的自身免疫性疾病。目前，临床治疗以胆碱酯酶抑制剂、糖皮质激素、免疫抑制剂等药物治疗及血浆置换和胸腺切除术为主，但这些传统疗法常伴有不良反应或手术复杂性以及病情易反复。现简要概括中医药治疗重症肌无力的临床证据与机制研究进展，以期为中医药治疗重症肌无力提供参考。
Abstract: Myasthenia gravis is an autoimmune disease mediated by autoantibodies that affects the neuromuscular junction. Currently, clinical treatment mainly involves the use of cholinesterase inhibitors, glucocorticoids, immunosuppressants, as well as plasma exchange and thymectomy. However, these conventional therapies are often associated with adverse reactions, surgical complexity, and frequent disease relapses. This article briefly summarizes the clinical evidence and mechanistic research progress of traditional Chinese medicine in the treatment of myasthenia gravis, aiming to provide a reference for its use.
文章引用：庄雨, 程为平. 中医药治疗重症肌无力的临床证据与机制研究进展[J]. 中医学, 2026, 15(6): 100-106. https://doi.org/10.12677/tcm.2026.156318

参考文献

[1] Huang, E.J., Wu, M., Wang, T. et al. (2023) Myasthenia Gravis: Novel Findings and Perspectives on Traditional to Regenerative Therapeutic Interventions. Aging and Disease, 14, 1070-1092.
[2] Zhao, M., Liu, L., Liu, F., Liu, L., Liu, Z., Gao, Y., et al. (2023) Traditional Chinese Medicine Improves Myasthenia Gravis by Regulating the Symbiotic Homeostasis of the Intestinal Microbiota and Host. Frontiers in Microbiology, 13, Article ID: 1082565. [Google Scholar] [CrossRef] [PubMed]
[3] 廖紫倩, 叶如冰, 游梦玲, 等. 黄芪及其制剂治疗重症肌无力的研究进展[J]. 基层中医药, 2025, 4(7): 113-118.
[4] Zhu, S., Wang, R., Yu, Z., et al. (2021) Chinese Herbal Medicine for Myasthenia Gravis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Integrative medicine research, 11, Article 100806.
[5] 郭逸凡, 杜妙, 杨洁, 等. 健脾益肾举陷汤联合西药治疗重症肌无力的临床及免疫指标的前瞻性研究[J]. 时珍国医国药, 2024, 35(8): 1927-1931.
[6] Qiu, C., Zhang, L. and Li, J. (2024) Grilled Nux Vomica Alleviates Myasthenia Gravis by Inhibiting the JAK2/STAT3 Signaling Pathway: A Study in a Mice Model. European Journal of Medical Research, 29, Article No. 507. [Google Scholar] [CrossRef] [PubMed]
[7] Wang, S., Zhang, X., Bai, Y., Shi, J., Sun, Y. and Wu, H. (2025) Shengxian Decoction Alleviates Experimental Autoimmune Myasthenia Gravis by Enhancing the Immunosuppressive Activity of Regulatory T Cells via Hippo Pathway. Journal of Ethnopharmacology, 352, Article 120250. [Google Scholar] [CrossRef] [PubMed]
[8] 王士达. 基于“大气下陷”病机探究升陷汤治疗重症肌无力的免疫分子机制[D]: [硕士学位论文]. 南京: 南京中医药大学, 2025.
[9] Xue, H., Zeng, L., He, H., Xu, D. and Ren, K. (2024) Effects of Acupuncture Treatment for Myasthenia Gravis: A Systematic Review and Meta-Analysis. PLOS ONE, 19, e0291685. [Google Scholar] [CrossRef] [PubMed]
[10] Gamus, D. and Shoenfeld, Y. (2025) Acupuncture Therapy in Autoimmune Diseases: A Narrative Review. Autoimmunity Reviews, 24, Article 103709. [Google Scholar] [CrossRef] [PubMed]
[11] 谭冬阳. 针灸治疗重症肌无力临床随机对照试验Meta-分析[D]: [硕士学位论文]. 沈阳: 辽宁中医药大学, 2020.
[12] Shen, X. and Li, Y. (2021) Myasthenia Gravis: The Pharmacological Basis of Traditional Chinese Medicine for Its Clinical Application. BioFactors, 48, 228-238. [Google Scholar] [CrossRef] [PubMed]
[13] Efferth, T. and Oesch, F. (2021) The Immunosuppressive Activity of Artemisinin‐Type Drugs Towards Inflammatory and Autoimmune Diseases. Medicinal Research Reviews, 41, 3023-3061. [Google Scholar] [CrossRef] [PubMed]
[14] 钟卓泰. 重症肌无力中医证型与肠道菌群相关性研究[D]: [硕士学位论文]. 广州: 广州中医药大学, 2021.
[15] 单玉男. 基于中医证素探讨重症肌无力肠道微生物区系[D]: [硕士学位论文]. 济南: 山东中医药大学, 2024.
[16] 王芳茂, 朱嘉民, 孙宏, 等. 针灸治疗重症肌无力的机制与临床研究进展[J/OL]. 辽宁中医药大学学报: 1-10.
https://link.cnki.net/urlid/21.1543.r.20251119.1750.018, 2025-12-07.
[17] 苏小果. 基于Meta分析和网络药理学探讨补中益气汤治疗脾胃虚弱型重症肌无力的疗效与机制[D]: [硕士学位论文]. 南宁: 广西中医药大学, 2025.
[18] Liu, X., Kuang, Y., Bian, C., et al. (2023) Exploring the Mechanism of Action of Herbal Compounding in the Treatment of Myasthenia Gravis Based on Network Pharmacology. Biotechnology & Genetic Engineering Reviews, 40, 1164-1179.
[19] 韩松冀. 基于数据挖掘和网络药理学探究中医药干预治疗MG的用药规律及作用机制[D]: [硕士学位论文]. 长春: 长春中医药大学, 2023.