可编程生物材料在感染性骨缺损治疗中的 研究进展
Research Progress on Programmable Biomaterials in Treatment of Infectious Bone Defects
DOI: 10.12677/acm.2026.1662284, PDF,   
作者: 肖志营, 张 赫*:重庆医科大学口腔医学院,重庆;口腔疾病研究重庆市重点实验室,重庆;口腔生物医学工程重庆市高校市级重点实验室,重庆;重庆市卫生健康委口腔生物医学工程重点实验室,重庆
关键词: 可编程生物材料感染性骨缺损骨再生Programmable Biomaterials Infectious Bone Defects Bone Regeneration
摘要: 感染性骨缺损是骨科、颌面外科和口腔种植科中常见的并发症,传统的治疗策略注重杀菌与修复再生的协同,忽略了动态演变感染微环境。近年来,可编程生物材料通过时间程序化释放、空间精准定位和可控响应三大维度的整合,为突破感染性骨缺损修复的瓶颈提供了新的解决方案。本文系统性综述了用于感染性骨缺损修复的可编程生物材料的时间程序化递送系统、空间靶向策略、响应性释放平台的最新研究进展,为下一代智能生物材料的设计与临床转化提供指导。
Abstract: Infectious bone defects are a common complication in orthopedics, maxillofacial surgery, and dental implantology. Traditional treatment strategies focus on the synergy of sterilization and repair regeneration, neglecting the dynamic evolution of the infectious microenvironment. In recent years, programmable biomaterials have provided new solutions for breaking through the bottleneck of infectious bone defect repair through the integration of three dimensions: time programmed release, spatial precise positioning, and controllable response. This article systematically reviews the latest research progress on time programmed delivery systems, spatial targeting strategies, and responsive release platforms of programmable biomaterials for infectious bone defect repair, providing guidance for the design and clinical translation of next-generation intelligent biomaterials.
文章引用:肖志营, 张赫. 可编程生物材料在感染性骨缺损治疗中的 研究进展[J]. 临床医学进展, 2026, 16(6): 838-847. https://doi.org/10.12677/acm.2026.1662284

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