绞股蓝、苦瓜及姜黄干预高脂血症的药理学机制研究进展

Research Progress on the Pharmacological Mechanisms of Gynostemma pentaphyllum, Momordica charantia, and Curcuma longa in Intervening Hyperlipidemia

摘要: 高脂血症(HLP)是指血浆中一种或多种脂质成分浓度超过正常参考范围的状态，近年来，我国呈现发病率逐年增加且年轻化趋势。临床上，部分高脂血症患者在采取西药治疗后，会出现治疗瓶颈或伴随肝肾损伤等副作用。针对这一现状，综述中草药绞股蓝、苦瓜及姜黄活性成分干预高脂血症的药理学机制研究进展，揭示上述药物不仅通过多种途径降低血脂，还兼有保护肝肾和全身性代谢调节的多重作用。这些发现为探索中西医联合管理高脂血症提供了重要的实验依据和理论参考。

Abstract: Hyperlipidemia (HLP) is a pathological condition characterized by elevated plasma concentrations of one or more lipid components beyond the normal reference range. In recent years, its incidence has been increasing year by year with a trend toward younger onset in China. Clinically, some patients treated with Western medicines face therapeutic bottlenecks and adverse reactions such as hepatic and renal impairment. In view of this status, this paper reviews the research progress on the pharmacological mechanisms of active ingredients from Gynostemma pentaphyllum, Momordica charantia, and Curcuma longa in intervening hyperlipidemia, indicating that these active ingredients not only lower blood lipids through multiple pathways but also confer hepatoprotective, nephroprotective, and systemic metabolic regulatory effects. These findings provide important experimental evidence and theoretical reference for exploring the integrated management of hyperlipidemia with traditional Chinese and Western medicine.