趋化素样因子超家族的研究进展及其与肿瘤的关系
Research Advancement in Chemokine-Like Factor Superfamily and Relationship with Tumor
DOI: 10.12677/acm.2026.1662293, PDF,   
作者: 温 静:川北医学院附属医院肿瘤科,四川 南充;四川省卫生健康委员会实体性肿瘤精准诊疗一体化医学重点实验室,四川 南充;李 鑫*:川北医学院第二附属医院泌尿外科,四川 南充;川北医学院校医院,四川 南充
关键词: 趋化素样因子超家族肿瘤Chemokine-Like Factor Superfamily Tumor
摘要: 趋化素样因子超家族是北京大学人类疾病基因研究中心在国际上首次报道的新基因家族。在人类,该家族包括9个基因,即:趋化素样因子(chemokine-like factor, CKLF)和趋化素样因子超家族成员1~8 (chemokine-like factor superfamily members 1~8, CKLFSF1~8) (2005年,被命名为CMTM1~8),其编码产物在机体的生理和病理调节中均显示出了重要意义,尤其在免疫、男性生殖等系统中发挥了重要作用,并与肿瘤的发生发展也有密切的关系。对该超家族的深入研究具有重要的理论意义和潜在的临床应用价值。
Abstract: Chemokine-like factor superfamily is a novel gene family first reported by Peking University Center for Human Disease Genomics. In human, the family contained nine genes, CKLF and CKLFSF1~8, in 2005, CKLFSF1~8 were renamed CKLF-like MARVEL transmembrane domain containing 1~8 (CMTM1~8). The novel gene family plays multiple roles in a wide range of physiological and pathological processes, especially in male reproductive and immune systems, and it also plays an important role in the occurrence and progression of tumors. Hence, further study on the superfamily has an important theoretical value and potential clinical value.
文章引用:温静, 李鑫. 趋化素样因子超家族的研究进展及其与肿瘤的关系[J]. 临床医学进展, 2026, 16(6): 904-912. https://doi.org/10.12677/acm.2026.1662293

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