非侵入性迷走神经电刺激治疗孤独症谱系障碍的潜在机制
Potential Mechanisms of Non-Invasive Vagus Nerve Electrical Stimulation in the Treatment of Autism Spectrum Disorder
摘要: 孤独症谱系障碍(Autism Spectrum Disorder, ASD)是高度异质的神经系统发育障碍，核心症状为社交困难、沟通交流障碍、重复刻板行为等。目前缺乏针对性治疗。非侵入性迷走神经电刺激(Non-Invasive Vagus Nerve Electrical Stimulation, nVNS)是新兴无创神经调控疗法，通过体表电刺激迷走神经(vagus nerve, VN)调节自主神经与神经–免疫–内分泌网络。易于操作，安全性更高，依从性好等优势。已用于癫痫、抑郁等疾病治疗，但尚未广泛用于ASD。本文概述ASD神经生物学发病机制与nVNS的作用机制，对已有nVNS治疗ASD的临床研究进行深入讨论，为nVNS治疗ASD提供理论依据与新策略。
Abstract: Autism Spectrum Disorder (ASD) is a highly heterogeneous neurodevelopmental disorder characterized by core symptoms such as social deficits, communication impairments, and repetitive stereotyped behaviors. Currently, there is a lack of targeted treatments. Non-Invasive Vagus Nerve Electrical Stimulation (nVNS) is an emerging non-invasive neuromodulation therapy that regulates the autonomic nervous system and the neuro-immune-endocrine network through transcutaneous electrical stimulation of the vagus nerve (VN). It offers advantages such as ease of operation, higher safety, and good compliance. Although nVNS has been used in the treatment of epilepsy, depression, and other disorders, it has not yet been widely applied to ASD. This article provides an overview of the neurobiological pathogenesis of ASD and the mechanisms of action of nVNS and conducts an in-depth discussion of existing clinical studies on nVNS for ASD, aiming to provide theoretical foundations and new strategies for the treatment of ASD with nVNS.
文章引用：刘玉茹, 王苑茹, 李彩月, 王艳. 非侵入性迷走神经电刺激治疗孤独症谱系障碍的潜在机制[J]. 临床医学进展, 2026, 16(6): 990-997. https://doi.org/10.12677/acm.2026.1662304

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