四类肌萎缩亚型中PI3K-Akt枢纽调控的共同 机制与潜在调控差异的探讨
Exploration of the Common Mechanisms and Potential Regulatory Differences of PI3K-Akt Hub Regulation in Four Subtypes of Muscular Atrophy
DOI: 10.12677/acm.2026.1662307, PDF,   
作者: 李彩月, 刘玉茹, 王苑茹：黑龙江中医药大学第二临床医学院，黑龙江 哈尔滨；王 艳*：黑龙江中医药大学第二临床医学院，黑龙江 哈尔滨；黑龙江中医药大学附属第二医院康复中心，黑龙江 哈尔滨
关键词: PI3K/Akt信号通路；神经源性肌萎缩；废用性肌萎缩；高血糖诱发的骨骼肌萎缩；衰老性肌萎缩；PI3K/Akt Signaling Pathway； Neurogenic Muscle Atrophy； Disuse Muscular Atrophy； Hyperglycemia-Induced Skeletal Muscle Atrophy； Sarcopenia
摘要: 骨骼肌萎缩四大亚型(神经源性肌萎缩Neurogenic Muscle Atrophy；废用性肌萎缩Disuse Muscular Atrophy；高血糖诱发的骨骼肌萎缩Hyperglycemia-Induced Skeletal Muscle Atrophy；衰老性肌萎缩Sarcopenia)随人口老龄化及慢性病高发呈全球流行，磷脂酰肌醇3-激酶/蛋白激酶B (Phosphatidylinositol 3-Kinase/Protein Kinase B, PI3K/Akt)通路是调控其发生的核心枢纽。本文综述四类亚型在PI3K/Akt通路上的共同病理基础，探讨其上游诱因、核心分子事件及终末主导通路可能存在的潜在差异性，并初步探讨其潜在治疗思路与机制。
Abstract: The four major subtypes of skeletal muscle atrophy, namely neurogenic muscle atrophy, disuse muscular atrophy, hyperglycemia-induced skeletal muscle atrophy and sarcopenia, have become a global epidemic with the aging population and the high incidence of chronic diseases. The Phosphatidylinositol 3-Kinase/Protein Kinase B (PI3K/Akt) signaling pathway is a core hub regulating the occurrence of skeletal muscle atrophy. This paper reviews the common pathological basis of the four subtypes in the PI3K/Akt signaling pathway, explores the potential differences that may exist in their upstream inducers, core molecular events and terminal dominant pathways, and preliminarily discusses the potential therapeutic ideas and mechanisms for skeletal muscle atrophy.
文章引用：李彩月, 王艳, 刘玉茹, 王苑茹. 四类肌萎缩亚型中PI3K-Akt枢纽调控的共同 机制与潜在调控差异的探讨[J]. 临床医学进展, 2026, 16(6): 1020-1029. https://doi.org/10.12677/acm.2026.1662307

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