SIRT1在脓毒症器官保护作用中的研究进展
Research Progress on the Protective Role of SIRT1 in Sepsis-Induced Organ Injury
DOI: 10.12677/ns.2026.156192, PDF,   
作者: 陈梦晓, 杜姗姗, 徐可欣, 刘洁玲, 王智琦：湖北医药学院口腔医学院，湖北 十堰；吴 刚*：十堰市人民医院(湖北医药学院附属人民医院)急诊科，湖北 十堰
关键词: 脓毒症；SIRT1；器官损伤；炎症；氧化应激；自噬；Sepsis； SIRT1； Organ Injury； Inflammation； Oxidative Stress； Autophagy
摘要: 脓毒症属于因宿主抗感染应答失控而诱发的致命性器官功能衰竭，其致死率较高，临床干预手段相对匮乏。沉默信息调节因子1 (SIRT1)是一种依赖于NAD+的去乙酰化酶，它通过调控炎症、氧化应激、自噬及凋亡等过程，对脓毒症所诱发的多器官损伤起到关键性的保护作用。本文系统综述SIRT1在脓毒症所致肝、肾、心、肺、肠损伤中的最新研究进展。在肝脏，SIRT1激活AMPK信号通路促进自噬，减轻炎症与代谢应激；在肾脏，SIRT1上调PGC-1α改善线粒体功能，减少氧化应激和细胞凋亡；在心肌，SIRT1通过Nrf2/HO-1轴增强抗氧化防御，同时激活AMPK促进自噬；在肺脏，SIRT1可通过调节巨噬细胞的极化状态与线粒体自噬过程，减轻炎症反应及内皮细胞损伤。在肠道中，SIRT1被激活后能够抑制活性氧的生成，同时使紧密连接蛋白保持正常表达水平，进而推动肠道屏障功能恢复。这些结果提示，SIRT1经由多种信号途径展现出抗炎、抗氧化、抗凋亡及自噬调节等功能，可作为脓毒症所致器官损伤的潜在干预靶点，为该病的临床治疗提供了新的理论依据。
Abstract: Sepsis refers to a fatal organ dysfunction arising from an aberrant host response to infection, characterized by high mortality and limited treatment options. SIRT1 (silent information regulator 1) is an NAD+-dependent deacetylase that confers significant protection against multi-organ damage induced by sepsis through modulation of inflammation, oxidative stress, autophagy, and apoptosis. This article systematically reviews recent progress on SIRT1 in sepsis-induced injuries of the liver, kidney, heart, lung, and intestine. In the liver, SIRT1 activates AMPK signaling to promote autophagy and alleviate inflammation and metabolic stress. In the kidney, SIRT1 upregulates PGC-1α to improve mitochondrial function and reduce oxidative stress and apoptosis. In the heart, SIRT1 enhances antioxidant defense via the Nrf2/HO-1 axis and activates AMPK to promote autophagy. In the lung, SIRT1 modulates macrophage polarization and mitophagy, thereby reducing inflammation and endothelial injury. In the intestine, SIRT1 activation suppresses reactive oxygen species production and maintains normal expression of tight junction proteins, thus promoting intestinal barrier repair. These findings indicate that SIRT1 exerts anti-inflammatory, antioxidant, anti-apoptotic, and autophagy-regulating effects through multiple pathways, positioning it as a potential therapeutic target for sepsis-induced organ damage and providing a new theoretical basis for clinical management.
文章引用：陈梦晓, 吴刚, 杜姗姗, 徐可欣, 刘洁玲, 王智琦. SIRT1在脓毒症器官保护作用中的研究进展[J]. 护理学, 2026, 15(6): 174-181. https://doi.org/10.12677/ns.2026.156192

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