血液肿瘤患者恐惧疾病的研究进展

Research Advances in Addressing the Fear of Disease among Hematologic Cancer Patients

摘要: 恐惧疾病进展(Fear of Progression, FoP)这是血液系统恶性肿瘤患者中最常见的心理问题之一，表现为对疾病可能恶化或扩散的持续担忧和恐惧。基于对国内外相关文献的系统性综述，本文从五个角度概述了血液系统恶性肿瘤患者“疾病进展恐惧”(FoP)研究的进展：概念定义、评估工具、流行病学状况、影响因素及干预策略。研究结果表明，FoP在血液肿瘤患者中十分常见，并与疾病复发、造血干细胞移植史、负面情绪状态以及缺乏社会支持等因素密切相关。目前已有若干专门的评估工具，例如FoP-Q-SF和FCR-7，以及认知行为疗法等心理干预策略，正念训练以及基于积极心理学的干预措施，均已取得初步成效。未来的研究应侧重于针对疾病亚型开展随机对照试验，探索个性化干预方案，并将增强家庭韧性作为临床实践的优先事项加以整合。

Abstract: Fear of Progression (FoP) is one of the most common psychological issues among patients with hematologic malignancies, characterized by persistent concern and fear of disease deterioration or dissemination. Based on a systematic review of relevant domestic and international literature, this article summarizes the progress in research on “disease progression fear” (FoP) in hematologic malignancy patients from five perspectives: conceptual definition, assessment tools, epidemiological prevalence, influencing factors, and intervention strategies. Research findings indicate that FoP is highly prevalent among hematologic tumor patients and is closely associated with disease recurrence, history of hematopoietic stem cell transplantation, negative emotional states, and lack of social support. Several specialized assessment tools, such as the FoP-Q-SF and FCR-7, along with psychological intervention strategies—including cognitive behavioral therapy, mindfulness training, and positive psychology-based interventions, have demonstrated preliminary efficacy. Future research should focus on randomized controlled trials targeting specific disease subtypes, exploring personalized intervention approaches, and integrating enhanced family resilience as a priority in clinical practice.