系统性免疫炎症反应指数在心血管疾病中的 研究进展
Research Progress of the Systemic Immune-Inflammation Response Index in Cardiovascular Diseases
摘要: 综述近2年来关于系统性免疫炎症反应指数(Systemic Immune-Inflammation Response Index, SIIRI)与心血管疾病关系的研究进展。炎症失衡是动脉粥样硬化(Atherosclerosis, AS)及心血管事件进展的核心病理机制，寻找便捷、高效的炎症评估指标将会对心血管疾病的精准防治带来重要意义。SIIRI作为一种新型的、扩展的复合炎症反应指标，通过外周血中性粒细胞、单核细胞、血小板与淋巴细胞计数的整合计算，反映机体免疫与炎症失衡状态。近年来SIIRI在心血管疾病领域的研究日渐深入，尤其在冠状动脉病变的风险评估及预后预测中展现出独特价值。本文基于现有相关研究文献，重点综述SIIRI在心血管疾病中的临床应用，分析当前研究的局限性，并展望未来发展方向，为SIIRI在心血管疾病临床实践中的规范化应用提供参考。
Abstract: The paper has reviewed the research progress on the relationship between the systemic immune-inflammation response index (SIIRI) and cardiovascular disease in the past two years. Identifying convenient and efficient inflammatory assessment indicators is of great significance for the precise prevention and treatment of cardiovascular diseases. The Systemic Immune-Inflammation Response Index (SIIRI), as a novel and extended composite inflammatory indicator, integrates peripheral blood neutrophil, monocyte, platelet, and lymphocyte counts to reflect the state of immune and inflammatory imbalance in the body. In recent years, research on SIIRI in the field of cardiovascular disease has deepened, demonstrating unique value, particularly in risk assessment and prognostic prediction of coronary artery disease. Based on relevant literature published in the past two years, this review focuses on the clinical applications of SIIRI in cardiovascular disease, analyzes current research limitations, and discusses future directions, aiming to provide a reference for the standardized application of SIIRI in clinical cardiovascular practice.
文章引用：李悦, 李树民. 系统性免疫炎症反应指数在心血管疾病中的 研究进展[J]. 临床医学进展, 2026, 16(6): 1446-1452. https://doi.org/10.12677/acm.2026.1662358

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