|
[1]
|
Avgerinos, K.I., Spyrou, N., Mantzoros, C.S. and Dalamaga, M. (2019) Obesity and Cancer Risk: Emerging Biological Mechanisms and Perspectives. Metabolism, 92, 121-135. [Google Scholar] [CrossRef] [PubMed]
|
|
[2]
|
Kitahara, C.M. and Sosa, J.A. (2016) The Changing Incidence of Thyroid Cancer. Nature Reviews Endocrinology, 12, 646-653. [Google Scholar] [CrossRef] [PubMed]
|
|
[3]
|
Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R.L., Soerjomataram, I., et al. (2024) Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 74, 229-263. [Google Scholar] [CrossRef] [PubMed]
|
|
[4]
|
Franchini, F., Palatucci, G., Colao, A., Ungaro, P., Macchia, P.E. and Nettore, I.C. (2022) Obesity and Thyroid Cancer Risk: An Update. International Journal of Environmental Research and Public Health, 19, Article 1116. [Google Scholar] [CrossRef] [PubMed]
|
|
[5]
|
Burrage, L.C., McLeod, D.S.A. and Jordan, S.J. (2023) Obesity and Thyroid Cancer Risk. Current Opinion in Endocrinology, Diabetes & Obesity, 30, 244-251. [Google Scholar] [CrossRef] [PubMed]
|
|
[6]
|
Marcello, M.A., Cunha, L.L., Batista, F.A. and Ward, L.S. (2014) Obesity and Thyroid Cancer. Endocrine Related Cancer, 21, T255-T271. [Google Scholar] [CrossRef] [PubMed]
|
|
[7]
|
Payne, R.J. (2011) Obesity and Thyroid Cancer. Frontiers in Bioscience, 3, 555-564. [Google Scholar] [CrossRef] [PubMed]
|
|
[8]
|
Pazaitou-Panayiotou, K., Polyzos, S.A. and Mantzoros, C.S. (2013) Obesity and Thyroid Cancer: Epidemiologic Associations and Underlying Mechanisms. Obesity Reviews, 14, 1006-1022. [Google Scholar] [CrossRef] [PubMed]
|
|
[9]
|
Bradley, D. (2020) Obesity, Thyroid Nodularity, and Thyroid Cancer: Epiphenomenon or Cause? The Journal of Clinical Endocrinology & Metabolism, 105, e3010-e3012. [Google Scholar] [CrossRef] [PubMed]
|
|
[10]
|
Kitahara, C.M., Pfeiffer, R.M., Sosa, J.A. and Shiels, M.S. (2020) Impact of Overweight and Obesity on US Papillary Thyroid Cancer Incidence Trends (1995-2015). JNCI: Journal of the National Cancer Institute, 112, 810-817. [Google Scholar] [CrossRef] [PubMed]
|
|
[11]
|
Ma, J., Huang, M., Wang, L., et al. (2015) Obesity and Risk of Thyroid Cancer: Evidence from a Meta-Analysis of 21 Observational Studies. Medical Science Monitor, 21, 283-291. [Google Scholar] [CrossRef] [PubMed]
|
|
[12]
|
Ameziane El Hassani, R., Buffet, C., Leboulleux, S. and Dupuy, C. (2019) Oxidative Stress in Thyroid Carcinomas: Biological and Clinical Significance. Endocrine-Related Cancer, 26, R131-R143. [Google Scholar] [CrossRef] [PubMed]
|
|
[13]
|
Malaguarnera, R., Vella, V., Nicolosi, M.L. and Belfiore, A. (2017) Insulin Resistance: Any Role in the Changing Epidemiology of Thyroid Cancer? Frontiers in Endocrinology, 8, Article 314. [Google Scholar] [CrossRef] [PubMed]
|
|
[14]
|
Kitahara, C.M., Neta, G., Pfeiffer, R.M., Kwon, D., Xu, L., Freedman, N.D., et al. (2012) Common Obesity-Related Genetic Variants and Papillary Thyroid Cancer Risk. Cancer Epidemiology, Biomarkers & Prevention, 21, 2268-2271. [Google Scholar] [CrossRef] [PubMed]
|
|
[15]
|
Kershaw, E.E. and Flier, J.S. (2004) Adipose Tissue as an Endocrine Organ. The Journal of Clinical Endocrinology & Metabolism, 89, 2548-2556. [Google Scholar] [CrossRef] [PubMed]
|
|
[16]
|
Hotamisligil, G.S., Arner, P., Caro, J.F., Atkinson, R.L. and Spiegelman, B.M. (1995) Increased Adipose Tissue Expression of Tumor Necrosis Factor-Alpha in Human Obesity and Insulin Resistance. Journal of Clinical Investigation, 95, 2409-2415. [Google Scholar] [CrossRef] [PubMed]
|
|
[17]
|
Lumeng, C.N., Bodzin, J.L. and Saltiel, A.R. (2007) Obesity Induces a Phenotypic Switch in Adipose Tissue Macrophage Polarization. Journal of Clinical Investigation, 117, 175-184. [Google Scholar] [CrossRef] [PubMed]
|
|
[18]
|
Kawai, T., Autieri, M.V. and Scalia, R. (2021) Adipose Tissue Inflammation and Metabolic Dysfunction in Obesity. American Journal of Physiology-Cell Physiology, 320, C375-C391. [Google Scholar] [CrossRef] [PubMed]
|
|
[19]
|
Rana, M.N. and Neeland, I.J. (2022) Adipose Tissue Inflammation and Cardiovascular Disease: An Update. Current Diabetes Reports, 22, 27-37. [Google Scholar] [CrossRef] [PubMed]
|
|
[20]
|
Coelho, M., Oliveira, T. and Fernandes, R. (2013) State of the Art Paper Biochemistry of Adipose Tissue: An Endocrine Organ. Archives of Medical Science, 2, 191-200. [Google Scholar] [CrossRef] [PubMed]
|
|
[21]
|
Huh, J.Y., Park, Y.J., Ham, M. and Kim, J.B. (2014) Crosstalk between Adipocytes and Immune Cells in Adipose Tissue Inflammation and Metabolic Dysregulation in Obesity. Molecules and Cells, 37, 365-371. [Google Scholar] [CrossRef] [PubMed]
|
|
[22]
|
Kern, P.A., Ranganathan, S., Li, C., Wood, L. and Ranganathan, G. (2001) Adipose Tissue Tumor Necrosis Factor and Interleukin-6 Expression in Human Obesity and Insulin Resistance. American Journal of Physiology-Endocrinology and Metabolism, 280, E745-E751. [Google Scholar] [CrossRef] [PubMed]
|
|
[23]
|
Lihn, A.S., Pedersen, S.B. and Richelsen, B. (2005) Adiponectin: Action, Regulation and Association to Insulin Sensitivity. Obesity Reviews, 6, 13-21. [Google Scholar] [CrossRef] [PubMed]
|
|
[24]
|
Fu, Y., Luo, N., Klein, R.L. and Garvey, W.T. (2005) Adiponectin Promotes Adipocyte Differentiation, Insulin Sensitivity, and Lipid Accumulation. Journal of Lipid Research, 46, 1369-1379. [Google Scholar] [CrossRef] [PubMed]
|
|
[25]
|
Kubota, N., Terauchi, Y., Yamauchi, T., Kubota, T., Moroi, M., Matsui, J., et al. (2002) Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation. Journal of Biological Chemistry, 277, 25863-25866. [Google Scholar] [CrossRef] [PubMed]
|
|
[26]
|
Kelesidis, I., Kelesidis, T. and Mantzoros, C.S. (2006) Adiponectin and Cancer: A Systematic Review. British Journal of Cancer, 94, 1221-1225. [Google Scholar] [CrossRef] [PubMed]
|
|
[27]
|
Friedenreich, C.M., Ryder-Burbidge, C. and McNeil, J. (2021) Physical Activity, Obesity and Sedentary Behavior in Cancer Etiology: Epidemiologic Evidence and Biologic Mechanisms. Molecular Oncology, 15, 790-800. [Google Scholar] [CrossRef] [PubMed]
|
|
[28]
|
Tumminia, A., Vinciguerra, F., Parisi, M., Graziano, M., Sciacca, L., Baratta, R., et al. (2019) Adipose Tissue, Obesity and Adiponectin: Role in Endocrine Cancer Risk. International Journal of Molecular Sciences, 20, Article 2863. [Google Scholar] [CrossRef] [PubMed]
|
|
[29]
|
Dalamaga, M., Diakopoulos, K.N. and Mantzoros, C.S. (2012) The Role of Adiponectin in Cancer: A Review of Current Evidence. Endocrine Reviews, 33, 547-594. [Google Scholar] [CrossRef] [PubMed]
|
|
[30]
|
Mitsiades, N., Pazaitou-Panayiotou, K., Aronis, K.N., Moon, H., Chamberland, J.P., Liu, X., et al. (2011) Circulating Adiponectin Is Inversely Associated with Risk of Thyroid Cancer: In Vivo and in Vitro Studies. The Journal of Clinical Endocrinology & Metabolism, 96, E2023-E2028. [Google Scholar] [CrossRef] [PubMed]
|
|
[31]
|
Zhou, Y., Yang, Y., Zhou, T., Li, B. and Wang, Z. (2021) Adiponectin and Thyroid Cancer: Insight into the Association between Adiponectin and Obesity. Aging and Disease, 12, 597-613. [Google Scholar] [CrossRef] [PubMed]
|
|
[32]
|
Li, C., Zhang, J., Dionigi, G., Liang, N., Guan, H. and Sun, H. (2024) Adiponectin Inhibits the Progression of Obesity-Associated Papillary Thyroid Carcinoma through Autophagy. Endocrinology, 165, bqae030. [Google Scholar] [CrossRef] [PubMed]
|
|
[33]
|
Obradovic, M., Sudar-Milovanovic, E., Soskic, S., Essack, M., Arya, S., Stewart, A.J., et al. (2021) Leptin and Obesity: Role and Clinical Implication. Frontiers in Endocrinology, 12, Article 585887. [Google Scholar] [CrossRef] [PubMed]
|
|
[34]
|
Bulló, M., García-Lorda, P., Megias, I. and Salas-Salvadó, J. (2003) Systemic Inflammation, Adipose Tissue Tumor Necrosis Factor, and Leptin Expression. Obesity Research, 11, 525-531. [Google Scholar] [CrossRef] [PubMed]
|
|
[35]
|
Myers, M.G., Cowley, M.A. and Münzberg, H. (2008) Mechanisms of Leptin Action and Leptin Resistance. Annual Review of Physiology, 70, 537-556. [Google Scholar] [CrossRef] [PubMed]
|
|
[36]
|
Knight, Z.A., Hannan, K.S., Greenberg, M.L. and Friedman, J.M. (2010) Hyperleptinemia Is Required for the Development of Leptin Resistance. PLOS ONE, 5, e11376. [Google Scholar] [CrossRef] [PubMed]
|
|
[37]
|
Shah, N.R. and Braverman, E.R. (2012) Measuring Adiposity in Patients: The Utility of Body Mass Index (BMI), Percent Body Fat, and Leptin. PLOS ONE, 7, e33308. [Google Scholar] [CrossRef] [PubMed]
|
|
[38]
|
Park, H., Kwon, H.M., Lim, H.J., Hong, B.K., Lee, J.Y., Park, B.E., et al. (2001) Potential Role of Leptin in Angiogenesis: Leptin Induces Endothelial Cell Proliferation and Expression of Matrix Metalloproteinases in Vivo and in Vitro. Experimental & Molecular Medicine, 33, 95-102. [Google Scholar] [CrossRef] [PubMed]
|
|
[39]
|
Saxena, N.K., Sharma, D., Ding, X., Lin, S., Marra, F., Merlin, D., et al. (2007) Concomitant Activation of the JAK/STAT, PI3K/AKT, and ERK Signaling Is Involved in Leptin-Mediated Promotion of Invasion and Migration of Hepatocellular Carcinoma Cells. Cancer Research, 67, 2497-2507. [Google Scholar] [CrossRef] [PubMed]
|
|
[40]
|
Ostlund, R.E. (1996) Relation between Plasma Leptin Concentration and Body Fat, Gender, Diet, Age, and Metabolic Covariates. Journal of Clinical Endocrinology & Metabolism, 81, 3909-3913. [Google Scholar] [CrossRef] [PubMed]
|
|
[41]
|
Gao, J., Tian, J., Lv, Y., Shi, F., Kong, F., Shi, H., et al. (2009) Leptin Induces Functional Activation of Cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT Pathways in Human Endometrial Cancer Cells. Cancer Science, 100, 389-395. [Google Scholar] [CrossRef] [PubMed]
|
|
[42]
|
Kennedy, A. (1997) The Metabolic Significance of Leptin in Humans: Gender-Based Differences in Relationship to Adiposity, Insulin Sensitivity, and Energy Expenditure. Journal of Clinical Endocrinology & Metabolism, 82, 1293-1300. [Google Scholar] [CrossRef] [PubMed]
|
|
[43]
|
Hedayati, M., Yaghmaei, P., Pooyamanesh, Z., Zarif Yeganeh, M. and Hoghooghi Rad, L. (2011) Leptin: A Correlated Peptide to Papillary Thyroid Carcinoma? Journal of Thyroid Research, 2011, Article ID: 832163. [Google Scholar] [CrossRef] [PubMed]
|
|
[44]
|
Pappa, T. and Alevizaki, M. (2014) Obesity and Thyroid Cancer: A Clinical Update. Thyroid®, 24, 190-199. [Google Scholar] [CrossRef] [PubMed]
|
|
[45]
|
Celano, M., Maggisano, V., Lepore, S.M., Sponziello, M., Pecce, V., Verrienti, A., et al. (2019) Expression of Leptin Receptor and Effects of Leptin on Papillary Thyroid Carcinoma Cells. International Journal of Endocrinology, 2019, Article ID: 5031696. [Google Scholar] [CrossRef] [PubMed]
|
|
[46]
|
Chi, (2010) Differential Roles of Leptin in Regulating Cell Migration in Thyroid Cancer Cells. Oncology Reports, 23, 1721-1727. [Google Scholar] [CrossRef] [PubMed]
|
|
[47]
|
Cheng, S.P., Yin, P.H., Hsu, Y.C., et al. (2011) Leptin Enhances Migration of Human Papillary Thyroid Cancer Cells through the PI3K/AKT and MEK/ERK Signaling Pathways. Oncology Reports, 26, 1265-1271.
|
|
[48]
|
Uddin, S., Bavi, P., Siraj, A.K., Ahmed, M., Al-Rasheed, M., Hussain, A.R., et al. (2010) Leptin-R and Its Association with PI3K/AKT Signaling Pathway in Papillary Thyroid Carcinoma. Endocrine-Related Cancer, 17, 191-202. [Google Scholar] [CrossRef] [PubMed]
|
|
[49]
|
Park, J.W., Han, C.R., Zhao, L., Willingham, M.C. and Cheng, S. (2016) Inhibition of STAT3 Activity Delays Obesity-Induced Thyroid Carcinogenesis in a Mouse Model. Endocrine-Related Cancer, 23, 53-63. [Google Scholar] [CrossRef] [PubMed]
|
|
[50]
|
Sindhu, S., Thomas, R., Shihab, P., Sriraman, D., Behbehani, K. and Ahmad, R. (2015) Obesity Is a Positive Modulator of IL-6R and IL-6 Expression in the Subcutaneous Adipose Tissue: Significance for Metabolic Inflammation. PLOS ONE, 10, e0133494. [Google Scholar] [CrossRef] [PubMed]
|
|
[51]
|
Bonetto, A., Aydogdu, T., Jin, X., Zhang, Z., Zhan, R., Puzis, L., et al. (2012) JAK/STAT3 Pathway Inhibition Blocks Skeletal Muscle Wasting Downstream of IL-6 and in Experimental Cancer Cachexia. American Journal of Physiology-Endocrinology and Metabolism, 303, E410-E421. [Google Scholar] [CrossRef] [PubMed]
|
|
[52]
|
Lokau, J., Schoeder, V., Haybaeck, J. and Garbers, C. (2019) Jak-Stat Signaling Induced by Interleukin-6 Family Cytokines in Hepatocellular Carcinoma. Cancers, 11, Article 1704. [Google Scholar] [CrossRef] [PubMed]
|
|
[53]
|
Bastard, J., Maachi, M., van Nhieu, J.T., Jardel, C., Bruckert, E., Grimaldi, A., et al. (2002) Adipose Tissue IL-6 Content Correlates with Resistance to Insulin Activation of Glucose Uptake Both in Vivo and in Vitro. The Journal of Clinical Endocrinology & Metabolism, 87, 2084-2089. [Google Scholar] [CrossRef] [PubMed]
|
|
[54]
|
Sansone, P. and Bromberg, J. (2012) Targeting the Interleukin-6/Jak/Stat Pathway in Human Malignancies. Journal of Clinical Oncology, 30, 1005-1014. [Google Scholar] [CrossRef] [PubMed]
|
|
[55]
|
Wu, X., Tao, P., Zhou, Q., Li, J., Yu, Z., Wang, X., et al. (2017) IL-6 Secreted by Cancer-Associated Fibroblasts Promotes Epithelial-Mesenchymal Transition and Metastasis of Gastric Cancer via JAK2/STAT3 Signaling Pathway. Oncotarget, 8, 20741-20750. [Google Scholar] [CrossRef] [PubMed]
|
|
[56]
|
Yadav, A., Kumar, B., Datta, J., Teknos, T.N. and Kumar, P. (2011) IL-6 Promotes Head and Neck Tumor Metastasis by Inducing Epithelial-Mesenchymal Transition via the JAK-STAT3-SNAIL Signaling Pathway. Molecular Cancer Research, 9, 1658-1667. [Google Scholar] [CrossRef] [PubMed]
|
|
[57]
|
Gyamfi, J., Lee, Y., Eom, M. and Choi, J. (2018) Interleukin-6/Stat3 Signalling Regulates Adipocyte Induced Epithelial-Mesenchymal Transition in Breast Cancer Cells. Scientific Reports, 8, Article No. 8859. [Google Scholar] [CrossRef] [PubMed]
|
|
[58]
|
Le Bras, G.F., Taubenslag, K.J. and Andl, C.D. (2012) The Regulation of Cell-Cell Adhesion during Epithelial-Mesenchymal Transition, Motility and Tumor Progression. Cell Adhesion & Migration, 6, 365-373. [Google Scholar] [CrossRef] [PubMed]
|
|
[59]
|
Micalizzi, D.S., Farabaugh, S.M. and Ford, H.L. (2010) Epithelial-mesenchymal Transition in Cancer: Parallels between Normal Development and Tumor Progression. Journal of Mammary Gland Biology and Neoplasia, 15, 117-134. [Google Scholar] [CrossRef] [PubMed]
|
|
[60]
|
Jung, H., Fattet, L. and Yang, J. (2015) Molecular Pathways: Linking Tumor Microenvironment to Epithelial-Mesenchymal Transition in Metastasis. Clinical Cancer Research, 21, 962-968. [Google Scholar] [CrossRef] [PubMed]
|
|
[61]
|
Dongre, A. and Weinberg, R.A. (2019) New Insights into the Mechanisms of Epithelial-Mesenchymal Transition and Implications for Cancer. Nature Reviews Molecular Cell Biology, 20, 69-84. [Google Scholar] [CrossRef] [PubMed]
|
|
[62]
|
Nieto-Vazquez, I., Fernández-Veledo, S., Krämer, D.K., Vila-Bedmar, R., Garcia-Guerra, L. and Lorenzo, M. (2008) Insulin Resistance Associated to Obesity: The Link TNF-α. Archives of Physiology and Biochemistry, 114, 183-194. [Google Scholar] [CrossRef] [PubMed]
|
|
[63]
|
Hotamisligil, G.S. (1999) The Role of TNFα and TNF Receptors in Obesity and Insulin Resistance. Journal of Internal Medicine, 245, 621-625. [Google Scholar] [CrossRef] [PubMed]
|
|
[64]
|
Pang, X., Ross, N.S. and Hershman, J.M. (1996) Alterations in TNF-α Signal Transduction in Resistant Human Papillary Thyroid Carcinoma Cells. Thyroid, 6, 313-317. [Google Scholar] [CrossRef] [PubMed]
|
|
[65]
|
Zatterale, F., Longo, M., Naderi, J., Raciti, G.A., Desiderio, A., Miele, C., et al. (2020) Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes. Frontiers in Physiology, 10, Article 1607. [Google Scholar] [CrossRef] [PubMed]
|
|
[66]
|
Xu, H., Barnes, G.T., Yang, Q., Tan, G., Yang, D., Chou, C.J., et al. (2003) Chronic Inflammation in Fat Plays a Crucial Role in the Development of Obesity-Related Insulin Resistance. Journal of Clinical Investigation, 112, 1821-1830. [Google Scholar] [CrossRef] [PubMed]
|
|
[67]
|
Ahmed, B., Sultana, R. and Greene, M.W. (2021) Adipose Tissue and Insulin Resistance in Obese. Biomedicine & Pharmacotherapy, 137, Article ID: 111315. [Google Scholar] [CrossRef] [PubMed]
|
|
[68]
|
Arcidiacono, B., Iiritano, S., Nocera, A., Possidente, K., Nevolo, M.T., Ventura, V., et al. (2012) Insulin Resistance and Cancer Risk: An Overview of the Pathogenetic Mechanisms. Experimental Diabetes Research, 2012, Article ID: 789174. [Google Scholar] [CrossRef] [PubMed]
|
|
[69]
|
Hua, H., Kong, Q., Yin, J., Zhang, J. and Jiang, Y. (2020) Insulin-Like Growth Factor Receptor Signaling in Tumorigenesis and Drug Resistance: A Challenge for Cancer Therapy. Journal of Hematology & Oncology, 13, Article No. 64. [Google Scholar] [CrossRef] [PubMed]
|
|
[70]
|
Zhou, X., Chen, N., Xu, H., Zhou, X., Wang, J., Fang, X., et al. (2020) Regulation of Hippo-YAP Signaling by Insulin-Like Growth Factor-1 Receptor in the Tumorigenesis of Diffuse Large B-Cell Lymphoma. Journal of Hematology & Oncology, 13, Article No. 77. [Google Scholar] [CrossRef] [PubMed]
|
|
[71]
|
Nwabo Kamdje, A.H., Seke Etet, P.F., Kipanyula, M.J., Vecchio, L., Tagne Simo, R., Njamnshi, A.K., et al. (2022) Insulin-Like Growth Factor-1 Signaling in the Tumor Microenvironment: Carcinogenesis, Cancer Drug Resistance, and Therapeutic Potential. Frontiers in Endocrinology, 13, Article 927390. [Google Scholar] [CrossRef] [PubMed]
|
|
[72]
|
Vigneri, P.G., Tirrò, E., Pennisi, M.S., Massimino, M., Stella, S., Romano, C., et al. (2015) The Insulin/IGF System in Colorectal Cancer Development and Resistance to Therapy. Frontiers in Oncology, 5, Article 230. [Google Scholar] [CrossRef] [PubMed]
|
|
[73]
|
Cox, M.E., Gleave, M.E., Zakikhani, M., Bell, R.H., Piura, E., Vickers, E., et al. (2009) Insulin Receptor Expression by Human Prostate Cancers. The Prostate, 69, 33-40. [Google Scholar] [CrossRef] [PubMed]
|
|
[74]
|
Law, J.H., Habibi, G., Hu, K., Masoudi, H., Wang, M.Y.C., Stratford, A.L., et al. (2008) Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival. Cancer Research, 68, 10238-10246. [Google Scholar] [CrossRef] [PubMed]
|
|
[75]
|
Rostoker, R., Abelson, S., Bitton-Worms, K., Genkin, I., Ben-Shmuel, S., Dakwar, M., et al. (2015) Highly Specific Role of the Insulin Receptor in Breast Cancer Progression. Endocrine-Related Cancer, 22, 145-157. [Google Scholar] [CrossRef] [PubMed]
|
|
[76]
|
Malaguarnera, R., Frasca, F., Garozzo, A., Gianì, F., Pandini, G., Vella, V., et al. (2011) Insulin Receptor Isoforms and Insulin-Like Growth Factor Receptor in Human Follicular Cell Precursors from Papillary Thyroid Cancer and Normal Thyroid. The Journal of Clinical Endocrinology & Metabolism, 96, 766-774. [Google Scholar] [CrossRef] [PubMed]
|
|
[77]
|
Morgillo, F., Kim, W., Kim, E.S., Ciardiello, F., Hong, W.K. and Lee, H. (2007) Implication of the Insulin-Like Growth Factor-IR Pathway in the Resistance of Non-Small Cell Lung Cancer Cells to Treatment with Gefitinib. Clinical Cancer Research, 13, 2795-2803. [Google Scholar] [CrossRef] [PubMed]
|
|
[78]
|
Denley, A., Wallace, J.C., Cosgrove, L.J., et al. (2003) The Insulin Receptor Isoform Exon 11-(IR-A) in Cancer and Other Diseases: A Review. Hormone and Metabolic Research, 35, 778-785. [Google Scholar] [CrossRef] [PubMed]
|
|
[79]
|
Belfiore, A. (2007) The Role of Insulin Receptor Isoforms and Hybrid Insulin/IGF-I Receptors in Human Cancer. Current Pharmaceutical Design, 13, 671-686. [Google Scholar] [CrossRef] [PubMed]
|
|
[80]
|
Vella, V., Milluzzo, A., Scalisi, N.M., Vigneri, P. and Sciacca, L. (2018) Insulin Receptor Isoforms in Cancer. International Journal of Molecular Sciences, 19, Article 3615. [Google Scholar] [CrossRef] [PubMed]
|
|
[81]
|
Marouf, S.P., Meskar, Z. and Rezaei, N. (2026) Insulin Resistance as a Modifiable Contributor to Breast Cancer: Mechanisms, Biomarkers, and Therapeutic Implications. Discover Oncology, 17, Article No. 662. [Google Scholar] [CrossRef]
|
|
[82]
|
Giudice, J., Leskow, F.C., Arndt-Jovin, D.J., Jovin, T.M. and Jares-Erijman, E.A. (2011) Differential Endocytosis and Signaling Dynamics of Insulin Receptor Variants IR-A and IR-B. Journal of Cell Science, 124, 801-811. [Google Scholar] [CrossRef] [PubMed]
|
|
[83]
|
Juul, A. (1995) Serum Levels of Insulin-Like Growth Factor (IGF)-Binding Protein-3 (IGFBP-3) in Healthy Infants, Children, and Adolescents: The Relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, Age, Sex, Body Mass Index, and Pubertal Maturation. Journal of Clinical Endocrinology & Metabolism, 80, 2534-2542. [Google Scholar] [CrossRef] [PubMed]
|
|
[84]
|
Völzke, H., Friedrich, N., Schipf, S., Haring, R., Lüdemann, J., Nauck, M., et al. (2007) Association between Serum Insulin-Like Growth Factor-I Levels and Thyroid Disorders in a Population-Based Study. The Journal of Clinical Endocrinology & Metabolism, 92, 4039-4045. [Google Scholar] [CrossRef] [PubMed]
|
|
[85]
|
LeRoith, D. and Roberts Jr., C.T. (1993) Insulin-Like Growth Factors and Their Receptors in Normal Physiology and Pathological States. Journal of Pediatric Endocrinology and Metabolism, 6, 251-256. [Google Scholar] [CrossRef] [PubMed]
|
|
[86]
|
Key, T.J., Appleby, P.N., Reeves, G.K., et al. (2010) Insulin-Like Growth Factor 1 (IGF1), IGF Binding Protein 3 (IGFBP3), and Breast Cancer Risk: Pooled Individual Data Analysis of 17 Prospective Studies. The Lancet Oncology, 11, 530-542. [Google Scholar] [CrossRef]
|
|
[87]
|
Hwa, V., Oh, Y. and Rosenfeld, R.G. (1999) The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily. Endocrine Reviews, 20, 761-787. [Google Scholar] [CrossRef] [PubMed]
|
|
[88]
|
Baxter, R.C. (2000) Insulin-like Growth Factor (IGF)-Binding Proteins: Interactions with IGFs and Intrinsic Bioactivities. American Journal of Physiology-Endocrinology and Metabolism, 278, E967-E976. [Google Scholar] [CrossRef] [PubMed]
|
|
[89]
|
Larsson, O., Girnita, A. and Girnita, L. (2007) Role of Insulin-Like Growth Factor 1 Receptor Signalling in Cancer. British Journal of Cancer, 92, 2097-2101.
|
|
[90]
|
Buck, E., Gokhale, P.C., Koujak, S., Brown, E., Eyzaguirre, A., Tao, N., et al. (2010) Compensatory Insulin Receptor (IR) Activation on Inhibition of Insulin-Like Growth Factor-1 Receptor (IGF-1R): Rationale for Cotargeting IGF-1R and IR in Cancer. Molecular Cancer Therapeutics, 9, 2652-2664. [Google Scholar] [CrossRef] [PubMed]
|
|
[91]
|
Hewish, M., Chau, I. and Cunningham, D. (2009) Insulin-Like Growth Factor 1 Receptor Targeted Therapeutics: Novel Compounds and Novel Treatment Strategies for Cancer Medicine. Recent Patents on Anti-Cancer Drug Discovery, 4, 54-72. [Google Scholar] [CrossRef] [PubMed]
|
|
[92]
|
Zhang, Y., Moerkens, M., Ramaiahgari, S., de Bont, H., Price, L., Meerman, J., et al. (2011) Elevated Insulin-Like Growth Factor 1 Receptor Signaling Induces Antiestrogen Resistance through the MAPK/ERK and PI3K/Akt Signaling Routes. Breast Cancer Research, 13, Article No. R52. [Google Scholar] [CrossRef] [PubMed]
|
|
[93]
|
Ock, S., Ahn, J., Lee, S.H., Kim, H.M., Kang, H., Kim, Y., et al. (2018) Thyrocyte-Specific Deletion of Insulin and IGF-1 Receptors Induces Papillary Thyroid Carcinoma-Like Lesions through EGFR Pathway Activation. International Journal of Cancer, 143, 2458-2469. [Google Scholar] [CrossRef] [PubMed]
|
|
[94]
|
Panebianco, F., Kelly, L.M., Liu, P., Zhong, S., Dacic, S., Wang, X., et al. (2017) THADA Fusion Is a Mechanism of IGF2BP3 Activation and IGF1R Signaling in Thyroid Cancer. Proceedings of the National Academy of Sciences of the United States of America, 114, 2307-2312. [Google Scholar] [CrossRef] [PubMed]
|
|
[95]
|
Eggo, M.C., Bachrach, L.K. and Burrow, G.N. (1990) Interaction of TSH, Insulin and Insulin-Like Growth Factors in Regulating Thyroid Growth and Function. Growth Factors, 2, 99-109. [Google Scholar] [CrossRef] [PubMed]
|
|
[96]
|
Fiore, E. and Vitti, P. (2012) Serum TSH and Risk of Papillary Thyroid Cancer in Nodular Thyroid Disease. The Journal of Clinical Endocrinology & Metabolism, 97, 1134-1145. [Google Scholar] [CrossRef] [PubMed]
|
|
[97]
|
Chakravarty, G., Santillan, A.A., Galer, C., Adams, H.P., El-Naggar, A.K., Jasser, S.A., et al. (2009) Phosphorylated Insulin Like Growth Factor-I Receptor Expression and Its Clinico-Pathological Significance in Histologic Subtypes of Human Thyroid Cancer. Experimental Biology and Medicine, 234, 372-386. [Google Scholar] [CrossRef] [PubMed]
|
|
[98]
|
Mayes, J.S. and Watson, G.H. (2004) Direct Effects of Sex Steroid Hormones on Adipose Tissues and Obesity. Obesity Reviews, 5, 197-216. [Google Scholar] [CrossRef] [PubMed]
|
|
[99]
|
Derwahl, M. and Nicula, D. (2014) Estrogen and Its Role in Thyroid Cancer. Endocrine Related Cancer, 21, T273-T283. [Google Scholar] [CrossRef] [PubMed]
|
|
[100]
|
Tchernof, A. and Després, J.P. (2000) Sex Steroid Hormones, Sex Hormone-Binding Globulin, and Obesity in Men and Women. Hormone and Metabolic Research, 32, 526-536. [Google Scholar] [CrossRef] [PubMed]
|
|
[101]
|
Klinge, (2010) Estradiol-Induced Proliferation of Papillary and Follicular Thyroid Cancer Cells Is Mediated by Estrogen Receptors α and β. International Journal of Oncology, 36, 1067-1080. [Google Scholar] [CrossRef] [PubMed]
|
|
[102]
|
Straub, R.H. (2007) The Complex Role of Estrogens in Inflammation. Endocrine Reviews, 28, 521-574. [Google Scholar] [CrossRef] [PubMed]
|
|
[103]
|
Papenfuss, T.L., Powell, N.D., McClain, M.A., Bedarf, A., Singh, A., Gienapp, I.E., et al. (2011) Estriol Generates Tolerogenic Dendritic Cells in Vivo That Protect against Autoimmunity. The Journal of Immunology, 186, 3346-3355. [Google Scholar] [CrossRef] [PubMed]
|
|
[104]
|
Huang, Y., Dong, W., Li, J., Zhang, H., Shan, Z. and Teng, W. (2014) Differential Expression Patterns and Clinical Significance of Estrogen Receptor-α and β in Papillary Thyroid Carcinoma. BMC Cancer, 14, Article No. 383. [Google Scholar] [CrossRef] [PubMed]
|
|
[105]
|
Gong, Z., Yang, S., Wei, M., Vlantis, A.C., Chan, J.Y.K., van Hasselt, C.A., et al. (2022) The Isoforms of Estrogen Receptor α and β in Thyroid Cancer. Frontiers in Oncology, 12, Article 916804. [Google Scholar] [CrossRef] [PubMed]
|
|
[106]
|
Chou, C., Chi, S., Hung, Y., Yang, Y., Fu, H., Wang, J., et al. (2022) Decreased Expression of Estrogen Receptors Is Associated with Tumorigenesis in Papillary Thyroid Carcinoma. International Journal of Molecular Sciences, 23, Article 1015. [Google Scholar] [CrossRef] [PubMed]
|
|
[107]
|
Di Vito, M., De Santis, E., Perrone, G.A., Mari, E., Giordano, M.C., De Antoni, E., et al. (2011) Overexpression of Estrogen Receptor-α in Human Papillary Thyroid Carcinomas Studied by Laser-Capture Microdissection and Molecular Biology. Cancer Science, 102, 1921-1927. [Google Scholar] [CrossRef] [PubMed]
|
|
[108]
|
Liu, J., Xu, T., Ma, L. and Chang, W. (2021) Signal Pathway of Estrogen and Estrogen Receptor in the Development of Thyroid Cancer. Frontiers in Oncology, 11, Article 593479. [Google Scholar] [CrossRef] [PubMed]
|
|
[109]
|
Cornetta, A.J., Russell, J.P., Cunnane, M., Keane, W.M. and Rothstein, J.L. (2002) Cyclooxygenase-2 Expression in Human Thyroid Carcinoma and Hashimoto’s Thyroiditis. The Laryngoscope, 112, 238-242. [Google Scholar] [CrossRef] [PubMed]
|
|
[110]
|
Chan, G., Boyle, J.O., Yang, E.K., et al. (1999) Cyclooxygenase-2 Expression Is Up-Regulated in Squamous Cell Carcinoma of the Head and Neck. Cancer Research, 59, 991-994.
|
|
[111]
|
Wilson, K.T., Fu, S., Ramanujam, K.S. and Meltzer, S.J. (1998) Increased Expression of Inducible Nitric Oxide Synthase and Cyclooxy-Genase-2 in Barrett’s Esophagus and Associated Adenocarcinomas. Cancer Research, 58, 2929-2934.
|
|
[112]
|
Taketo, M.M. (1998) Cyclooxygenase-2 Inhibitors in Tumorigenesis (Part I). JNCI Journal of the National Cancer Institute, 90, 1529-1536. [Google Scholar] [CrossRef] [PubMed]
|
|
[113]
|
Joo, Y., Rew, J., Seo, Y., Choi, S., Kim, Y., Park, C., et al. (2003) Cyclooxygenase-2 Overexpression Correlates with Vascular Endothelial Growth Factor Expression and Tumor Angiogenesis in Gastric Cancer. Journal of Clinical Gastroenterology, 37, 28-33. [Google Scholar] [CrossRef] [PubMed]
|
|
[114]
|
Trifan, O.C. and Hla, T. (2003) Cyclooxygenase-2 Modulates Cellular Growth and Promotes Tumorigenesis. Journal of Cellular and Molecular Medicine, 7, 207-222. [Google Scholar] [CrossRef] [PubMed]
|
|
[115]
|
Lo, C., Lam, K., Leung, P.P. and Luk, J.M. (2005) High Prevalence of Cyclooxygenase 2 Expression in Papillary Thyroid Carcinoma. European Journal of Endocrinology, 152, 545-550. [Google Scholar] [CrossRef] [PubMed]
|
|
[116]
|
Siironen, P., Ristimäki, A., Narko, K., Nordling, S., Louhimo, J., Andersson, S., et al. (2006) VEGF-C and COX-2 Expression in Papillary Thyroid Cancer. Endocrine-Related Cancer, 13, 465-473. [Google Scholar] [CrossRef] [PubMed]
|
|
[117]
|
Subbaramaiah, K., Morris, P.G., Zhou, X.K., Morrow, M., Du, B., Giri, D., et al. (2012) Increased Levels of COX-2 and Prostaglandin E2 Contribute to Elevated Aromatase Expression in Inflamed Breast Tissue of Obese Women. Cancer Discovery, 2, 356-365. [Google Scholar] [CrossRef] [PubMed]
|
|
[118]
|
Hsieh, P., Jin, J., Chiang, C., Chan, P., Chen, C. and Shih, K. (2009) COX-2-Mediated Inflammation in Fat Is Crucial for Obesity-Linked Insulin Resistance and Fatty Liver. Obesity, 17, 1150-1157. [Google Scholar] [CrossRef] [PubMed]
|
|
[119]
|
Chan, P., Liao, M. and Hsieh, P. (2019) The Dualistic Effect of COX-2-Mediated Signaling in Obesity and Insulin Resistance. International Journal of Molecular Sciences, 20, Article 3115. [Google Scholar] [CrossRef] [PubMed]
|
|
[120]
|
Trayhurn, P. and Wood, I.S. (2004) Adipokines: Inflammation and the Pleiotropic Role of White Adipose Tissue. British Journal of Nutrition, 92, 347-355. [Google Scholar] [CrossRef] [PubMed]
|
|
[121]
|
Fontana, L., Eagon, J.C., Trujillo, M.E., Scherer, P.E. and Klein, S. (2007) Visceral Fat Adipokine Secretion Is Associated with Systemic Inflammation in Obese Humans. Diabetes, 56, 1010-1013. [Google Scholar] [CrossRef] [PubMed]
|
|
[122]
|
Kintscher, U., Hartge, M., Hess, K., Foryst-Ludwig, A., Clemenz, M., Wabitsch, M., et al. (2008) T-Lymphocyte Infiltration in Visceral Adipose Tissue: A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin Resistance. Arteriosclerosis, Thrombosis, and Vascular Biology, 28, 1304-1310. [Google Scholar] [CrossRef] [PubMed]
|
|
[123]
|
Kanda, H. (2006) MCP-1 Contributes to Macrophage Infiltration into Adipose Tissue, Insulin Resistance, and Hepatic Steatosis in Obesity. Journal of Clinical Investigation, 116, 1494-1505. [Google Scholar] [CrossRef] [PubMed]
|
|
[124]
|
Coppack, S.W. (2001) Pro-Inflammatory Cytokines and Adipose Tissue. Proceedings of the Nutrition Society, 60, 349-356. [Google Scholar] [CrossRef] [PubMed]
|
|
[125]
|
Kang, Y.E., Kim, J.M., Joung, K.H., Lee, J.H., You, B.R., Choi, M.J., et al. (2016) The Roles of Adipokines, Proinflammatory Cytokines, and Adipose Tissue Macrophages in Obesity-Associated Insulin Resistance in Modest Obesity and Early Metabolic Dysfunction. PLOS ONE, 11, e0154003. [Google Scholar] [CrossRef] [PubMed]
|
|
[126]
|
Kamei, N., Tobe, K., Suzuki, R., Ohsugi, M., Watanabe, T., Kubota, N., et al. (2006) Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance. Journal of Biological Chemistry, 281, 26602-26614. [Google Scholar] [CrossRef] [PubMed]
|
|
[127]
|
Bai, Y. and Sun, Q. (2015) Macrophage Recruitment in Obese Adipose Tissue. Obesity Reviews, 16, 127-136. [Google Scholar] [CrossRef] [PubMed]
|
|
[128]
|
Apel, K. and Hirt, H. (2004) Reactive Oxygen Species: Metabolism, Oxidative Stress, and Signal Transduction. Annual Review of Plant Biology, 55, 373-399. [Google Scholar] [CrossRef] [PubMed]
|
|
[129]
|
Jomova, K., Raptova, R., Alomar, S.Y., Alwasel, S.H., Nepovimova, E., Kuca, K., et al. (2023) Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging. Archives of Toxicology, 97, 2499-2574. [Google Scholar] [CrossRef] [PubMed]
|
|
[130]
|
McMurray, F., Patten, D.A. and Harper, M. (2016) Reactive Oxygen Species and Oxidative Stress in Obesity—Recent Findings and Empirical Approaches. Obesity, 24, 2301-2310. [Google Scholar] [CrossRef] [PubMed]
|
|
[131]
|
Sies, H. (2017) Hydrogen Peroxide as a Central Redox Signaling Molecule in Physiological Oxidative Stress: Oxidative Eustress. Redox Biology, 11, 613-619. [Google Scholar] [CrossRef] [PubMed]
|
|
[132]
|
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., et al. (2004) Increased Oxidative Stress in Obesity and Its Impact on Metabolic Syndrome. Journal of Clinical Investigation, 114, 1752-1761. [Google Scholar] [CrossRef] [PubMed]
|
|
[133]
|
Manna, P. and Jain, S.K. (2015) Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies. Metabolic Syndrome and Related Disorders, 13, 423-444. [Google Scholar] [CrossRef] [PubMed]
|
|
[134]
|
Tan, B.L. and Norhaizan, M.E. (2019) Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function. Nutrients, 11, Article 2579. [Google Scholar] [CrossRef] [PubMed]
|
|
[135]
|
Shivappa, N., Hébert, J.R., Rietzschel, E.R., De Buyzere, M.L., Langlois, M., Debruyne, E., et al. (2015) Associations between Dietary Inflammatory Index and Inflammatory Markers in the Asklepios Study. British Journal of Nutrition, 113, 665-671. [Google Scholar] [CrossRef] [PubMed]
|
|
[136]
|
Vahid, F., Shivappa, N., Faghfoori, Z., et al. (2018) Validation of a Dietary Inflammatory Index (DII) and Association with Risk of Gastric Cancer: A Case-Control Study. Asian Pacific Journal of Cancer Prevention, 19, 1471-1477.
|
|
[137]
|
Denova-Gutiérrez, E., Muñoz-Aguirre, P., Shivappa, N., Hébert, J., Tolentino-Mayo, L., Batis, C., et al. (2018) Dietary Inflammatory Index and Type 2 Diabetes Mellitus in Adults: The Diabetes Mellitus Survey of Mexico City. Nutrients, 10, Article 385. [Google Scholar] [CrossRef] [PubMed]
|
|
[138]
|
Trevellin, E., Scarpa, M., Carraro, A., Lunardi, F., Kotsafti, A., Porzionato, A., et al. (2015) Esophageal Adenocarcinoma and Obesity: Peritumoral Adipose Tissue Plays a Role in Lymph Node Invasion. Oncotarget, 6, 11203-11215. [Google Scholar] [CrossRef] [PubMed]
|
|
[139]
|
van Kruijsdijk, R.C.M., van der Wall, E. and Visseren, F.L.J. (2009) Obesity and Cancer: The Role of Dysfunctional Adipose Tissue. Cancer Epidemiology, Biomarkers & Prevention, 18, 2569-2578. [Google Scholar] [CrossRef] [PubMed]
|
|
[140]
|
Frühbeck, G., Catalán, V., Rodríguez, A., Ramírez, B., Becerril, S., Salvador, J., et al. (2019) Adiponectin-Leptin Ratio Is a Functional Biomarker of Adipose Tissue Inflammation. Nutrients, 11, Article 454. [Google Scholar] [CrossRef] [PubMed]
|
|
[141]
|
Li, H., Chen, Y., Hu, L., Yang, W., Gao, Z., Liu, M., et al. (2023) Will Metformin Use Lead to a Decreased Risk of Thyroid Cancer? A Systematic Review and Meta-Analyses. European Journal of Medical Research, 28, Article No. 392. [Google Scholar] [CrossRef] [PubMed]
|
|
[142]
|
Peng, Y., Xu, S., Li, H., Li, X. and Du, Y. (2026) The IGF Signaling Axis in Thyroid Cancer: Biological Complexity and Therapeutic Challenges. Endocrine Connections, 15, e260144. [Google Scholar] [CrossRef]
|
|
[143]
|
Kushi, L.H., Doyle, C., McCullough, M., Rock, C.L., Demark-Wahnefried, W., Bandera, E.V., et al. (2012) American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention. CA: A Cancer Journal for Clinicians, 62, 30-67. [Google Scholar] [CrossRef] [PubMed]
|
|
[144]
|
Mctiernan, A., Friedenreich, C.M., Katzmarzyk, P.T., Powell, K.E., Macko, R., Buchner, D., et al. (2019) Physical Activity in Cancer Prevention and Survival: A Systematic Review. Medicine & Science in Sports & Exercise, 51, 1252-1261. [Google Scholar] [CrossRef] [PubMed]
|
|
[145]
|
Rock, C.L., Thomson, C., Gansler, T., Gapstur, S.M., McCullough, M.L., Patel, A.V., et al. (2020) American Cancer Society Guideline for Diet and Physical Activity for Cancer Prevention. CA: A Cancer Journal for Clinicians, 70, 245-271. [Google Scholar] [CrossRef] [PubMed]
|