核转录因子NF-κB在疾病中的作用机制及治疗前景综述
Review of the Mechanistic Role and Therapeutic Prospects of Nuclear Transcription Factor NF-κB in Diseases
DOI: 10.12677/jcpm.2026.53206, PDF,   
作者: 李慧真, 马 征*：承德医学院附属医院神经内科，河北 承德
关键词: NF-κB；信号通路；肿瘤；脑缺血；神经炎症；治疗靶点；NF-κB； Signaling Pathway； Tumor； Cerebral Ischemia； Neuroinflammation； Therapeutic Target
摘要: 核转录因子NF-κB是一种广泛存在于真核生物中的关键转录因子，参与调控免疫应答、炎症反应、细胞凋亡、肿瘤发生与发展等多种生理病理过程。本文系统综述了NF-κB的结构特征、信号通路、在肿瘤及神经系统疾病(尤其是脑缺血)中的作用机制，并探讨了以NF-κB为靶点的治疗策略及其临床应用前景。
Abstract: The nuclear factor transcription factor NF-κB is a key transcription factor widely present in eukaryotes, participating in the regulation of various physiological and pathological processes such as immune responses, inflammatory reactions, cell apoptosis, and tumorigenesis and development. This article provides a systematic review of the structural characteristics, signaling pathways, and mechanistic roles of NF-κB in tumors and neurological disorders (particularly cerebral ischemia), while also exploring therapeutic strategies targeting NF-κB and their clinical application prospects.
文章引用：李慧真, 马征. 核转录因子NF-κB在疾病中的作用机制及治疗前景综述[J]. 临床个性化医学, 2026, 5(3): 263-271. https://doi.org/10.12677/jcpm.2026.53206

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