糖尿病视网膜病变治疗策略与 前沿技术研究进展
Research Advances in Therapeutic Strategies and Cutting-Edge Technologies for Diabetic Retinopathy
DOI: 10.12677/acm.2026.1662381, PDF,   
作者: 李文青：西安医学院研究生院，陕西 西安；孙文涛*：西安市第四医院，陕西 西安
关键词: 糖尿病视网膜病变；纳米技术；干细胞治疗；基因治疗；综述；Diabetic Retinopathy； Nanotechnology； Stem Cell Therapy； Gene Therapy； Review
摘要: 随着社会经济发展，糖尿病视网膜病变(Diabetic Retinopathy, DR)作为糖尿病最常见的微血管并发症之一，已成为目前中老年群体致盲的主要原因。传统的治疗方式如抗血管内皮生长因子(VEGF)药物注射、激光光凝术及玻璃体切除术在临床应用中取得了一定成效，但其存在疗效局限、副作用多、患者依从性差及部分患者无效等不足。为此，本文重点综述了近些年分子靶向治疗、药物递送系统、基因疗法及细胞疗法、纳米技术等治疗技术在糖尿病视网膜病变领域的最新进展及挑战，旨在开发更精准、高效、持久的DR治疗策略，总结DR治疗方式的学术理论，为DR的临床治疗及科学研究提供参考。
Abstract: With socioeconomic development, Diabetic Retinopathy (DR), as one of the most common microvascular complications of diabetes mellitus, has emerged as a leading cause of blindness among middle-aged and elderly populations. Although conventional therapeutic modalities—including anti-Vascular Endothelial Growth Factor (VEGF) intravitreal injections, laser photocoagulation, and vitrectomy—have achieved certain clinical efficacy, they are still hampered by limitations such as restricted therapeutic response, considerable adverse effects, suboptimal patient adherence, and non-response in a subset of patients. This review therefore focuses on recent advances and current challenges associated with emerging treatment strategies for DR, encompassing molecular targeted therapy, novel drug delivery systems, gene therapy, cell-based therapy, and nanotechnology. The aim of this article is to develop more precise, efficacious, and durable therapeutic strategies for DR, summarize the academic theories underlying DR treatment approaches, and provide a reference for both clinical treatment and scientific research on DR.
文章引用：李文青, 孙文涛. 糖尿病视网膜病变治疗策略与 前沿技术研究进展[J]. 临床医学进展, 2026, 16(6): 1668-1675. https://doi.org/10.12677/acm.2026.1662381

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