无创正压通气联合布地奈德吸入对老年慢性 阻塞性肺疾病急性加重期伴II型呼吸衰竭 患者血气分析指标的影响

Influence of Combined Non-Invasive Positive Pressure Ventilation and Inhaled Budesonide on Blood Gas Analysis Indices in Elderly Patients with AECOPD and Type II Respiratory Failure

摘要: 目的：分析老年慢性阻塞性肺疾病急性加重期(AECOPD)伴II型呼吸衰竭患者应用无创正压通气(NIPPV)联合布地奈德吸入的效果。方法：选取2025年1月至2026年3月至我院就诊的46例老年AECOPD伴II型呼吸衰竭患者。本研究采用严格随机分配隐藏策略，并对结局评估者及数据分析者实施规范化设盲，严控各类混杂偏倚，提升临床研究证据等级。根据密闭信封法将患者均分为研究组(NIPPV联合布地奈德吸入)、基础组(NIPPV)，n = 23。组间对比血气分析指标和肺功能水平。结果：研究组的血气分析指标优于基础组(P < 0.05)；研究组的肺功能水平均高于基础组(P < 0.05)。结论：NIPPV联合布地奈德吸入能够改善老年AECOPD伴II型呼吸衰竭患者的血气分析指标，提高肺功能水平。

Abstract: Objective: To evaluate the therapeutic effect of non-invasive positive pressure ventilation (NIPPV) combined with inhaled budesonide in elderly AECOPD patients accompanied by type II respiratory failure. Methods: A total of 46 elderly patients with AECOPD accompanied by type II respiratory failure who visited our hospital from January 2025 to March 2026 were selected. This study employed a rigorous randomized allocation and concealment strategy, with standardized blinding implemented for both outcome evaluators and data analysts to strictly control various confounding biases and enhance the quality of clinical research evidence. Using the sealed envelope method, patients were equally divided into the study group (NIPPV combined with budesonide inhalation) and the baseline group (NIPPV), with n = 23 in each group. Inter-group comparisons were conducted on blood gas analysis indices and pulmonary function levels. Results: Compared with the control group, the study group showed superior blood gas parameters and higher pulmonary function levels (P < 0.05). Conclusion: NIPPV combined with budesonide inhalation can improve blood gas parameters and elevate pulmonary function levels in elderly patients with AECOPD complicated with type II respiratory failure.