小胶质细胞与缺血性脑卒中的相关性研究进展
Research Progress on the Correlation between Microglia and Ischemic Stroke
DOI: 10.12677/acm.2026.1662396, PDF,   
作者: 贾宗翰：承德医学院研究生学院，河北 承德；邯郸市中心医院神经内二科，河北 邯郸；霍会永*：邯郸市中心医院神经内二科，河北 邯郸
关键词: 缺血性脑卒中；小胶质细胞；药物；综述；Ischemic Stroke； Microglia； Medicine； Review
摘要: 缺血性脑卒中是危害人类生命健康安全的第一杀手。小胶质细胞是中枢神经系统的常驻免疫细胞，具有免疫防御、环境监测、突出修剪、支持与修复等作用。研究发现，当脑部微环境被改变时，诱导小胶质细胞极化平衡能有效控制神经炎症，改善神经细胞凋亡坏死，恢复脑组织血流血氧，从而降低临床致死率及致残率。本文聚焦小胶质细胞在缺血性脑卒中中的功能二重性、参与损伤的具体机制及靶向干预策略，旨在为临床诊治开拓新思路。
Abstract: Ischemic stroke is the first killer of human life, health and safety. Microglia are resident immune cells in the central nervous system, which play a role in immune defense, environmental monitoring, protrusion pruning, support and repair. Research has found that when the brain microenvironment is altered, inducing the polarization balance of microglia can effectively control neuroinflammation, improve the apoptosis and necrosis of nerve cells, restore blood oxygen in brain tissue, and thereby reduce the clinical mortality and disability rates. This article focuses on the functional duality of microglia in ischemic stroke, the specific mechanism of microglia involvement in injury, and targeted intervention strategies, aiming to open up new ideas for clinical diagnosis and treatment.
文章引用：贾宗翰, 霍会永. 小胶质细胞与缺血性脑卒中的相关性研究进展[J]. 临床医学进展, 2026, 16(6): 1782-1789. https://doi.org/10.12677/acm.2026.1662396

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