摘要: 目的：分析针灸联合舍曲林治疗抑郁症临床效果。方法：选取医院2024.01~2024.12期间60例符合病例，随机分组，对照组、研究组，30例/组，分别予以舍曲林治疗、针灸联合舍曲林治疗，观察临床效果。结果：研究组治疗总有效率高于对照组，P < 0.05；治疗前、两组抑郁程度(HAMD-17、MADRS)比较，P > 0.05，治疗2周、4周、8周后HAMD-17、MADRS评分均低于对照组，P < 0.05；治疗后，研究组情志抑郁、善悲易哭、失眠神疲、心神不定、多思多虑、头晕胸闷评分低于对照组，P < 0.05；治疗前，两组神经递质水平比较，P > 0.05，治疗后，研究组5-HT、DA、NE高于对照组，P < 0.05；治疗前，两组脑区FA值比较，P > 0.05，治疗后，研究组双侧额叶白质、双侧颞枕叶白质、胼胝体膝部、双侧内囊前肢、双侧海马、双侧纹状体FA值均高于对照组，P < 0.05；两组不良反应比较，P > 0.05。结论：抑郁症患者在舍曲林药物治疗基础上，联合针灸治疗，有助于提高患者临床疗效，改善患者抑郁程度，降低患者中医证候积分，提升患者神经递质水平，改善患者各向异性分数，而且两种治疗方案联合并未明显增加严重不良反应，安全性较好，经过对症处理，不良反应未对临床效果产生影响，具有较高的可行性价值。
Abstract: Objective: This paper aims to analyze the clinical effect of acupuncture and moxibustion combined with sertraline in the treatment of depression. Methods: 60 eligible patients from 2024.01~2024.12 were randomly divided into control group and study group, 30 cases/group, and were treated with sertraline, acupuncture and moxibustion combined with sertraline, respectively, to observe the clinical effect. Result: The total effective rate of the study group was higher than that of the control group, P < 0.05; Comparison of depression levels (HAMD-17, MADRS) between the two groups before treatment, P > 0.05, After 2, 4, and 8 weeks of treatment, the HAMD-17 and MADRS scores were lower than those in the control group, P < 0.05; After treatment, the study group had lower scores than the control group in terms of emotional depression, easy crying, insomnia, fatigue, restlessness, overthinking, dizziness, and chest tightness, P < 0.05; Before treatment, the levels of neurotransmitters were compared between the two groups, P > 0.05, After treatment, the levels of 5-HT, DA, and NE in the study group were higher than those in the control group, P < 0.05; Before treatment, the FA values of the two brain regions were compared, P > 0.05, After treatment, the FA values of bilateral frontal white matter, bilateral temporal occipital white matter, corpus callosum knee, bilateral anterior limb of internal capsule, bilateral hippocampus, and bilateral striatum in the study group were all higher than those in the control group, P < 0.05; Comparison of adverse reactions between two groups, P > 0.05. Conclusion: On the basis of sertraline drug treatment, the combination of acupuncture and moxibustion treatment for patients with depression can help to improve the clinical efficacy of patients, improve the degree of depression of patients, reduce the score of TCM syndromes of patients, improve the level of neurotransmitters of patients, and improve the anisotropic score of patients. Moreover, the combination of the two treatment schemes does not significantly increase serious adverse reactions, with good safety. After symptomatic treatment, adverse reactions have no impact on the clinical effect, which has high feasibility value.