USP21在肿瘤进展中的作用及其机制研究
Research on the Role of USP21 in Tumor Progression and Its Underlying Mechanisms
DOI: 10.12677/acm.2026.1662407, PDF,   
作者: 张 哲：西安医学院研究生院，陕西 西安；刘 卉*：西安医学院第一附属医院血液科，陕西 西安
关键词: 去泛素化酶(DUBs)；泛素特异性蛋白酶21；肿瘤进展；Deubiquitinases (DUBs)； Ubiquitin-Specific Protease 21； Tumor Progression
摘要: 泛素特异性蛋白酶21 (Ubiquitin-Specific Protease 21, USP21)作为去泛素化酶(Deubiquitinases, DUBs)家族关键成员，通过调控靶蛋白的泛素化修饰平衡蛋白质稳定性与功能，参与细胞代谢、信号传导、DNA修复等核心生理过程。近年研究证实，USP21在多种肿瘤中异常高表达，通过稳定癌蛋白、激活促癌信号通路等机制推动肿瘤增殖、侵袭及耐药性产生。本文系统综述USP21在肿瘤进展中的作用，为临床转化提供理论依据。
Abstract: As a key member of the deubiquitinases (DUBs) family, Ubiquitin-Specific Protease 21 (USP21) modulates the ubiquitination of target proteins to balance their stability and function, participating in core physiological processes including cellular metabolism, signal transduction, and DNA repair. Recent studies have confirmed that USP21 is aberrantly overexpressed in various tumors, promoting tumor proliferation, invasion, and drug resistance through mechanisms including stabilization of oncoproteins and activation of pro-tumorigenic signaling pathways. This review systematically summarizes the role of USP21 in tumor progression, providing a theoretical basis for clinical translation.
文章引用：张哲, 刘卉. USP21在肿瘤进展中的作用及其机制研究[J]. 临床医学进展, 2026, 16(6): 1881-1887. https://doi.org/10.12677/acm.2026.1662407

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