IGF2BP2在妇科恶性肿瘤中的研究进展
Research Progress of IGF2BP2 in Gynecological Malignancies
DOI: 10.12677/acm.2026.1662411, PDF,    科研立项经费支持
作者: 罗梦芸, 杨利花, 杨晓莉, 张 磊*：昆明医科大学第三附属医院、云南省肿瘤医院、北京大学肿瘤医院云南医院妇科，云南 昆明；张 玲*：昆明医科大学药学院、云南省现代生物医药产业学院暨云南省天然药物药理重点实验室，云南 昆明
关键词: IGF2BP2；m6A修饰；宫颈癌；卵巢癌；子宫内膜癌；IGF2BP2； m6A Modification； Cervical Cancer； Ovarian Cancer； Endometrial Cancer
摘要: 胰岛素样生长因子2 mRNA结合蛋白2 (Insulin-like growth factor 2 mRNA-binding protein 2, IGF2BP2)，是一种RNA结合蛋白，它主要通过结合靶RNA分子(如mRNA)来调控RNA的稳定性、定位、翻译和降解，由此来影响基因表达和细胞功能。IGF2BP2可以通过参与mRNA的m6A甲基化修饰来调节细胞的增殖、迁移、转移、侵袭和凋亡来参与癌症的发生发展。近年来IGF2BP2在妇科肿瘤中的作用备受关注，本文就IGF2BP2在妇科肿瘤中的研究进展进行综述。
Abstract: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2), a kind of RNA-binding protein, mainly regulates the stability, localization, translation and degradation of RNA by binding to target RNA molecules (such as mRNA), thereby influencing gene expression and cell function. IGF2BP2 can participate in the m6A methylation modification of mRNA to regulate cell proliferation, migration, invasion, metastasis and apoptosis, and thus be involved in the occurrence and development of cancer. In recent years, the role of IGF2BP2 in gynecological tumors has attracted much attention. This article reviews the research progress of IGF2BP2 in gynecological tumors.
文章引用：罗梦芸, 杨利花, 杨晓莉, 张玲, 张磊. IGF2BP2在妇科恶性肿瘤中的研究进展[J]. 临床医学进展, 2026, 16(6): 1909-1916. https://doi.org/10.12677/acm.2026.1662411

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