催化不对称Pall-Knorr反应构建轴手性吡咯杂环的研究进展
Research Progress on Catalytic Asymmetric Paal-Knorr Reaction for the Construction of Axially Chiral Pyrrole Heterocycles
DOI: 10.12677/jocr.2026.142021, PDF,   
作者: 马 睿, 谢惠定*：昆明医科大学药学院暨云南省天然药物药理重点实验室，云南 昆明
关键词: 催化不对称；Paal-Knorr反应；轴手性；C-N轴；N-N轴；Catalytic Asymmetric； Pall-Knorr Reaction； Axial Chirality； C-N Axis； N-N Axis
摘要: 催化不对称Paal-Knorr反应是近年来轴手性化学领域的重要突破。该经典人名反应历经百余年发展，直至2017年才由谭斌课题组首次实现其不对称催化版本，为该领域开辟了全新研究方向。此后，这一策略被广泛应用于各类轴手性杂环骨架的构建，取得了长足进展。本文系统综述了催化不对称Paal-Knorr反应在构建轴手性杂环领域的研究进展。本文通过构建C-N轴和N-N轴两种不同轴手性类型为线索，对本文展开综述。此外，还讨论了该反应实现立体控制的机理。最后，对该领域未来发展方向进行了展望。本文旨在为从事轴手性合成和杂环化学研究的人员提供参考。
Abstract: The catalytic asymmetric Paal-Knorr reaction represents a significant breakthrough in the field of axial chirality chemistry in recent years. This classic named reaction, after more than a century of development, was first realized in its asymmetric catalytic version by Tan’s group in 2017, opening up a new research direction in this field. Since then, this strategy has been widely applied to the construction of various axially chiral heterocyclic frameworks and has achieved considerable progress. This article systematically reviews the research advances in the construction of axially chiral heterocycles via catalytic asymmetric Paal-Knorr reaction. This review is organized based on two different types of axial chirality: C-N axis and N-N axis. In addition, the mechanism of stereo control in this reaction is discussed. Finally, the future development directions in this field are prospected. This review aims to provide reference for researchers engaged in axially chiral synthesis and heterocyclic chemistry.
文章引用：马睿, 谢惠定. 催化不对称Pall-Knorr反应构建轴手性吡咯杂环的研究进展[J]. 有机化学研究, 2026, 14(2): 231-242. https://doi.org/10.12677/jocr.2026.142021

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