单金属催化烯烃氢芳基化反应研究进展
Research Progress on Single-Metal-Catalyzed Hydroarylation Reactions of Olefins
DOI: 10.12677/jocr.2026.142022, PDF,   
作者: 董钦浩:浙江师范大学化学与材料科学学院,浙江 金华
关键词: 氢芳基化过渡金属烷基芳烃Hydroarylation Transition Metal Alkyla
摘要: 过渡金属催化烯烃的氢芳基化反应作为一种高效构建C(sp2)-C(sp3)键的策略,能够直接从来源广泛的烯烃和芳基化试剂一步合成烷基芳烃,在药物和功能分子合成中具有重要应用价值。本文系统综述了单金属催化烯烃氢芳基化反应的研究进展,重点聚焦于钯(Pd)、镍(Ni)、铑(Rh)和锰(Mn)四种过渡金属催化体系。详细阐述了各体系的发展脉络、反应机理及其在区域选择性和对映选择性控制方面的关键突破。
Abstract: Transition-metal-catalyzed hydroarylation of olefins serves as an efficient strategy for constructing C(sp2)-C(sp3) bonds, enabling the one-step synthesis of alkylarenes directly from readily available olefins and arylating reagents, which holds significant application value in the synthesis of pharmaceuticals and functional molecules. This review systematically summarizes the research progress in monometallic-catalyzed hydroarylation of olefins, with a focus on four transition-metal catalytic systems: palladium (Pd), nickel (Ni), rhodium (Rh), and manganese (Mn). It elaborates on the developmental trajectory, reaction mechanisms, and key advances in controlling regioselectivity and enantioselectivity within each system.
文章引用:董钦浩. 单金属催化烯烃氢芳基化反应研究进展[J]. 有机化学研究, 2026, 14(2): 243-258. https://doi.org/10.12677/jocr.2026.142022

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