中药熏蒸治疗干眼症门诊患者的疗效影响因素回顾性研究

Retrospective Study on the Influencing Factors of Curative Effect of Chinese Medicine Fumigation on Dry Eye Outpatients

摘要: 目的：探讨中药熏蒸治疗干眼症门诊患者的临床疗效，并分析影响疗效的相关因素，为优化临床治疗方案提供参考依据。方法：采用回顾性研究方法，收集2025年12月至2026年4月于珠海市中西医结合医院眼科门诊就诊并接受中药熏蒸治疗的94例干眼症患者的临床资料。所有患者均接受常规眼科治疗(人工泪液)联合中药熏蒸治疗，熏蒸方剂主要成分为菊花、枸杞子、密蒙花等，温度设定为(40 ± 2)˚C，每次10分钟，每日1次，4次为1个疗程。根据疗效分为无效组(10例)、显效组(35例)和有效组(49例)，通过方差分析、卡方检验和有序Logistic回归分析疗效的影响因素。结果：本研究总有效率为89.36% (84/94)。三组间病程、治疗前症状评分及治疗前右眼首次泪膜破裂时间(BUT)差异有统计学意义(P < 0.05)，而年龄差异无统计学意义(P = 0.629)。性别分布差异无统计学意义(P = 0.775)，干眼类型分布差异有统计学意义(P < 0.05)。有序Logistic回归分析显示，干眼类型和治疗前症状评分是影响疗效的独立因素(P < 0.05)。结论：中药熏蒸治疗干眼症疗效确切，总有效率达89.36%。干眼类型和治疗前症状评分是影响疗效的独立因素，风热犯目型患者疗效更佳。临床应根据患者中医证型制定个体化治疗方案，以提高疗效。

Abstract: Objective: To explore the clinical efficacy of Chinese medicine fumigation in the treatment of dry eye outpatients, and analyze the related factors that affect the efficacy, so as to provide reference for optimizing the clinical treatment plan. Methods: A retrospective study was conducted to collect the clinical data of 94 patients with dry eye from December 2025 to April 2026 in the eye clinic of Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine. All patients were treated with routine ophthalmic treatment (artificial tears) combined with fumigation with traditional Chinese medicine. The main components of the fumigation prescription were chrysanthemum, medlar, Buddleja officinalis, etc. The temperature was set at (40 ± 2)˚C for 10 minutes each time, once a day, and 4 times were a course of treatment. According to the curative effect, they were divided into ineffective group (10 cases), effective group (35 cases) and effective group (49 cases). The influencing factors of curative effect were analyzed by variance analysis, chi-square test and ordered Logistic regression. Results: The total effective rate of this study was 89.36% (84/94). There were statistically significant differences among the three groups in the course of disease, symptom score before treatment and the time of first tear film rupture (BUT) before treatment (P < 0.05), but there was no statistical difference in age (P = 0.629). There was no statistical difference in sex distribution (P = 0.775), but there was statistical difference in dry eye types (P < 0.05). Ordered Logistic regression analysis showed that dry eye type and symptom score before treatment were independent factors affecting the curative effect (P < 0.05). Conclusion: Chinese herbal fumigation is effective in treating dry eye, and the total effective rate is 89.36%. Dry eye type and symptom score before treatment are independent factors affecting the curative effect, and patients with wind-heat eye type have better curative effect. Clinically, individualized treatment scheme should be formulated according to the TCM syndrome types of patients to improve the curative effect.