基于光介导氢原子转移的惰性C(sp3)-H键直接胺化研究进展
Research Progress on Direct Amination of Inert C(sp3)-H Bonds via Photomediated Hydrogen Atom Transfer
DOI: 10.12677/jocr.2026.142025, PDF,   
作者: 陈羽佳*：兰州交通大学化学化工学院，甘肃 兰州；杨 晨*, 刘 烽#：复旦大学化学系，上海
关键词: 光介导；氢原子转移；胺化；Photo-Induced； Hydrogen Atom Transfer； Amination
摘要: 惰性C(sp3)-H键广泛存在于烷烃、天然产物和药物分子中，其直接胺化是构建C-N键和实现分子后期修饰的重要策略。近年来，光介导氢原子转移(HAT)反应因条件温和、选择性可调和绿色高效等优势，成为C(sp3)-H键官能化研究的热点。本文综述了直接HAT、间接HAT、LMCT及光诱导X-Y键均裂等策略在C(sp3)-H胺化中的研究进展，并总结其反应特点、机理基础与应用前景。
Abstract: Inert C(sp3)-H bonds are widely present in alkanes, natural products, and pharmaceutical molecules, and their direct amination provides an efficient approach to C-N bond formation and late-stage molecular modification. In recent years, photo-mediated hydrogen atom transfer (HAT) has emerged as a powerful strategy for C(sp3)-H functionalization owing to its mild conditions, tunable selectivity, and green features. This review summarizes recent advances in C(sp3)-H amination enabled by direct HAT, indirect HAT, LMCT processes, and photoinduced X-Y bond homolysis, with emphasis on reaction modes, mechanistic features, and future applications.
文章引用：陈羽佳, 杨晨, 刘烽. 基于光介导氢原子转移的惰性C(sp3)-H键直接胺化研究进展[J]. 有机化学研究, 2026, 14(2): 277-289. https://doi.org/10.12677/jocr.2026.142025

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