基于“心与小肠相表里”探析围绝经期女性 抑郁症与肠道菌群失调的关系

An Analysis of the Relationship between Depression and Intestinal Dysbiosis in Perimenopausal Women Based on the Principle That “the Heart and the Small Intestine Share a Paired Relationship”

摘要: 抑郁症是由多种因素引起的情感障碍性疾病，于围绝经期女性群体中较为多发，严重影响患者的生活质量。中医脏腑间的作用关系可影响本病的发展，其中“心与小肠相表里”理论可对应西医的“脑肠轴”概念，对研究本病的发病机制具有指导意义。现代研究发现，肠道菌群与神经系统联系密切，可通过雌激素影响围绝经期抑郁症(Perimenopausal depression, PMD)的发病。因此笔者以“心与小肠相表里”理论为切入点，通过“脑肠轴”探讨PMD与肠道菌群失调的相关性，以期为本病的中西医结合防治提供理论依据。

Abstract: Depression is an affective disorder caused by multiple factors that seriously affects the quality of life of patients and is more prevalent in the perimenopausal female population. The interrelationships among the viscera in traditional Chinese medicine (TCM) can influence the progression of this disease, among which the theory of “the heart and small intestine being interior-exteriorly related” corresponds to the concept of the “brain-gut axis” in Western medicine, providing theoretical guidance for investigating the pathogenesis of this disorder. Modern research has revealed that the gut microbiota is closely linked to the nervous system and may influence the onset of perimenopausal depression (PMD) through estrogen-mediated pathways, therefore, taking this as the starting point, we discuss the correlation between depression and intestinal flora dysbiosis in perimenopausal women through the “brain-gut axis” in order to provide a theoretical basis for the combined prevention and treatment of this disease. The aim is to provide a theoretical basis for the integrated prevention and treatment of this disease.