1990~2021年G20国家消化性溃疡患病率及疾病负担趋势研究

A Trend Study on the Prevalence and Disease Burden of Peptic Ulcer in G20 Countries from 1990 to 2021

摘要: 目的：为明确1990~2023年G20国家消化性溃疡患病率及疾病负担的变化趋势与地区差异，为全球胃肠道疾病防控提供依据。方法：本研究基于全球疾病负担(GBD) 2023数据集，提取G20国家消化性溃疡相关数据，采用DS-GBD-analysis软件进行统计分析与可视化。结果：G20国家年龄标化患病率均呈下降趋势，EAPC均为负值，巴西、印度降幅最显著；疾病负担地区差异显著，印度、中国、韩国1990年患病率居高位，欧洲国家偏低，人口大国患病绝对数远高于其他国家；1990~2023年各国患病数时间趋势呈异质性，部分国家持续上升、部分先升后降、部分近年回升。结论：G20国家消化性溃疡防控成效显著，但疾病负担分布不均，各国需结合自身特点制定相应策略，发展中国家聚焦幽门螺杆菌防控与卫生改善，发达国家强化老年及长期用药人群管理，实施精准干预以持续降低疾病负担。

Abstract: Objective: To clarify the changing trends and regional differences in the prevalence and disease burden of peptic ulcer in G20 countries from 1990 to 2023, and to provide evidence for the global prevention and control of gastrointestinal diseases. Methods: Based on the Global Burden of Disease (GBD) 2023 dataset, data related to peptic ulcer in G20 countries were extracted, and statistical analysis and visualization were performed using DS-GBD-analysis software. Results: The age-standardized prevalence of peptic ulcer in G20 countries all showed a downward trend with negative EAPC values, and the declines were most significant in Brazil and India. There were significant regional differences in disease burden: the prevalence rates in India, China, and South Korea were high in 1990, while those in European countries were relatively low; the absolute number of cases in populous countries was much higher than that in other countries. Temporal trends in the number of cases varied heterogeneously across countries from 1990 to 2023, with sustained increases in some countries, initial increases followed by decreases in others, and recent rebounds in several nations. Conclusion: Remarkable achievements have been made in the prevention and control of peptic ulcer in G20 countries, yet the distribution of disease burden is uneven. Countries should formulate strategies according to their own conditions: developing countries should focus on Helicobacter pylori control and health improvement, while developed countries should strengthen the management of the elderly and populations on long-term medication, so as to implement precise interventions and continuously reduce the disease burden.