肠道微生物代谢物在脓毒症发生发展机制中的作用
The Role of the Intestinal Microbial Metabolites in the Pathogenesis of Sepsis
DOI: 10.12677/acm.2026.1672494, PDF,   
作者: 梁嘉雯, 张 帆*：重庆医科大学附属璧山医院(重庆市璧山区人民医院)麻醉科，重庆
关键词: 脓毒症；肠道微生物组；微生物–肠–脑轴；短链脂肪酸；胆汁酸；Sepsis； Gut Microbiome； Microbiota - Gut - Brain Axis； Short-Chain Fatty Acid； Bile Acid
摘要: 脓毒症是由宿主对感染反应失调引发的危及生命的器官功能障碍，有预后差、病死率高等特点，明确脓毒症及其并发症的发生机制一直是亟待解决的问题。随着“微生物–肠–脑轴”双向调节机制进入人们视野，大量研究证明脓毒症及其并发症与该机制具有高度相关性，其中肠道微生物衍生的大量代谢物扮演了关键角色。本文聚焦于肠道微生物代谢物在脓毒症发生发展中的作用机制，系统综述这些代谢物如何通过调节肠道屏障功能、全身炎症反应、免疫细胞极化及远隔器官损伤等途径参与脓毒症的病理过程。旨在为该领域的深入研究提供理论依据，并探索基于代谢物的潜在治疗靶点。
Abstract: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, characterized by poor prognosis and high mortality. Clarifying the mechanisms underlying sepsis and its complications have always been an urgent issue to be addressed. With the emergence of the bidirectional regulatory “microbiota - gut - brain axis” concept, a growing body of evidence has demonstrated a strong correlation between sepsis and its complications and this axis, in which gut microbiota-derived metabolites play a critical role. This review focuses on the mechanisms by which gut microbial metabolites contribute to the onset and progression of sepsis, systematically summarizing how these metabolites participate in the pathological processes of sepsis by modulating intestinal barrier function, systemic inflammatory responses, immune cell polarization, and remote organ injury. The aim is to provide a theoretical foundation for further research in this field and to explore metabolite-based potential therapeutic targets.
文章引用：梁嘉雯, 张帆. 肠道微生物代谢物在脓毒症发生发展机制中的作用[J]. 临床医学进展, 2026, 16(7): 27-34. https://doi.org/10.12677/acm.2026.1672494

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