喹啉类化合物多官能团化进展及应用研究

Advances in the Multifunctionalization of Quinoline Derivatives and Applications

摘要: 喹啉以其独特的结构是一类重要的含氮杂环芳香化合物，其广泛存在于各种活性小分子和许多功能有机小分子结构中。独特的含氮结构使得喹啉具有与众不同的化学性质，往往能发生多种化学反应，而在有机合成及药物化学领域具有广泛的应用。目前，喹啉化合物的合成及官能团化研究已经有诸多文献报道，本文对近年来喹啉类化合物多官能团化及应用的文献报道进行了归纳与总结，期望对喹啉类化合物的合成与修饰来开发新型喹啉骨架功能小分子提供有效参考。

Abstract: Quinoline, with its unique structure, is an important class of nitrogen-containing heterocyclic aromatic compounds widely present in various bioactive small molecules and many functional organic molecular frameworks. Its distinctive nitrogen-containing structure endows quinoline with exceptional chemical properties, enabling it to participate in a wide range of chemical reactions and thus find broad applications in organic synthesis and medicinal chemistry. To date, numerous studies have been reported on the synthesis and functionalization of quinoline compounds. This article reviews and summarizes the recent literature on the functionalization of quinoline derivatives, aiming to provide an effective reference for the synthesis and modification of quinoline compounds to develop novel functional small molecules based on the quinoline skeleton.