口腔种植领域中黏性骨的不同组成及制作研究现状
Current Research Status of Different Compositions and Fabrication Methods of Sticky Bone in the Field of Oral Implantology
DOI: 10.12677/acm.2026.1672511, PDF,   
作者: 程安琪, 靳 勇*:内蒙古医科大学通辽临床医学院,内蒙古 通辽;通辽市人民医院口腔科,内蒙古 通辽;孟锦文, 薛子轩:通辽市人民医院口腔科,内蒙古 通辽
关键词: 黏性骨CGFPRFPRP植骨材料Sticky Bone CGF PRF PRP Bone Graft Materials
摘要: 黏性骨是由自体血液离心后提取的血小板浓缩物与颗粒状骨移植材料混合制备而成的面团样骨移植物,具有良好的可塑性和稳定性,可以适应各种类型的骨缺损形态,并在植入后保持空间上的稳定性;黏性骨同时兼顾血小板浓缩物带来的刺激骨再生的优势作用以及颗粒状骨材料带来的支架作用;目前,黏性骨已逐渐应用于口腔种植领域,并取得了积极的成骨效果。本文阐述了黏性骨的组成材料、不同组成及制备方式,旨在提供全面的黏性骨构成及制作指南,为临床工作提供便捷。
Abstract: Sticky bone is a dough-like bone graft prepared by mixing platelet concentrates extracted from autologous blood centrifugation with granular bone graft materials. It exhibits excellent plasticity and stability, can conform to the morphology of various types of bone defects, and maintains spatial stability after implantation. Sticky bone simultaneously combines the advantageous bone regeneration-stimulating effects of platelet concentrates with the scaffold function provided by granular bone materials. At present, sticky bone has been increasingly applied in the field of oral implantology and has achieved favorable osteogenic outcomes. This article reviews the constituent materials, different compositions and preparation methods of sticky bone, aiming to provide a comprehensive guide to the composition and fabrication of sticky bone and facilitate clinical practice.
文章引用:程安琪, 孟锦文, 薛子轩, 靳勇. 口腔种植领域中黏性骨的不同组成及制作研究现状[J]. 临床医学进展, 2026, 16(7): 171-180. https://doi.org/10.12677/acm.2026.1672511

参考文献

[1] Sanz, M., Dahlin, C., Apatzidou, D., Artzi, Z., Bozic, D., Calciolari, E., et al. (2019) Biomaterials and Regenerative Technologies Used in Bone Regeneration in the Craniomaxillofacial Region: Consensus Report of Group 2 of the 15th European Workshop on Periodontology on Bone Regeneration. Journal of Clinical Periodontology, 46, 82-91. [Google Scholar] [CrossRef] [PubMed]
[2] Haugen, H.J., Lyngstadaas, S.P., Rossi, F. and Perale, G. (2019) Bone Grafts: Which Is the Ideal Biomaterial? Journal of Clinical Periodontology, 46, 92-102. [Google Scholar] [CrossRef] [PubMed]
[3] Sohn, D.S., Huang, B.Z., Kim, J., et al. (2015) Utilization of Autologous Concentrated Growth Factors (CGF) Enriched Bone Graft Matrix (Sticky Bone) and CGF-Enriched Fibrin Membrane in Implant Dentistry. The Journal of Implant & Advanced Clinical Dentistry, 7, 11-29.
[4] 张玉峰, 王宇蓝. 血浆基质在口腔种植水平骨增量中的应用[J]. 口腔疾病防治, 2022, 30(3): 153-159.
[5] 任世强, 于筱, 马帅, 等. 植骨材料在口腔种植中的应用概况及进展[J]. 材料导报, 2021, 35(S1): 94-99.
[6] 郭子君, 丁铭, 李雅冬. 自体牙骨移植材料修复牙槽骨缺损的应用效果研究[J]. 中国实用口腔科杂志, 2024, 17(1): 74-79.
[7] 龚佳明, 张启航, 苟萍, 等. 自体牙本质用于牙槽嵴增量的Meta分析[J]. 华西口腔医学杂志, 2022, 40(5): 566-575.
[8] 唐卿炜, 杨帆. 深冻同种异体骨在口腔颌面骨缺损修复中的应用进展[J]. 口腔医学研究, 2025, 41(9): 750-754.
[9] Stavropoulos, A., Marcantonio, C.C., de Oliveira, V.X.R., Marcantonio, É. and de Oliveira, G.J.P.L. (2023) Fresh‐Frozen Allogeneic Bone Blocks Grafts for Alveolar Ridge Augmentation: Biological and Clinical Aspects. Periodontology 2000, 93, 139-152. [Google Scholar] [CrossRef] [PubMed]
[10] Ku, J., Kim, I., Um, I., Kim, B. and Yun, P. (2022) Effect of Gamma Irradiation on the Osteoinductivity of Demineralized Dentin Matrix for Allografts: A Preliminary Study. Journal of Functional Biomaterials, 13, Article 14. [Google Scholar] [CrossRef] [PubMed]
[11] 唐国柯, 文根, 刘彦斌, 等. 骨缺损修复生物材料的研究进展[J]. 中华骨与关节外科杂志, 2023, 16(2): 185-192.
[12] 李矛, 白玉龙, 李淼, 等. 两种去抗原异种骨性能评价及修复大鼠颅骨缺损实验研究[J]. 中国修复重建外科杂志, 2021, 35(10): 1303-1310.
[13] 田冲, 高博, 于鸿伟, 等. 骨修复材料治疗跟骨骨折的理论研究与技术应用[J]. 中国组织工程研究, 2022, 26(22): 3586-3591.
[14] 陈凯歌, 陈仁吉, 郭思远, 等. 人工骨材料β-磷酸三钙在牙槽嵴裂骨缺损修复中的应用[J]. 口腔疾病防治, 2023, 31(4): 252-256.
[15] Lee, S.S., Huber, S. and Ferguson, S.J. (2021) Comprehensive in Vitro Comparison of Cellular and Osteogenic Response to Alternative Biomaterials for Spinal Implants. Materials Science and Engineering: C, 127, Article ID: 112251. [Google Scholar] [CrossRef] [PubMed]
[16] 黄帅, 周小妮, 刘彦乐, 等. 块状异质植骨材料用于牙槽嵴骨增量的研究进展[J]. 中华口腔医学研究杂志(电子版), 2021, 15(2): 65-71.
[17] 周世博, 俞兴, 冯宁宁, 等. 骨量低下颈椎病患者应用纳米晶胶原基骨修复材料行颈椎前路椎间盘切除减压融合术后植骨融合效果研究[J]. 中国骨伤, 2025, 38(8): 800-809.
[18] 李亚仑, 董钊, 浦飞飞, 等. 脊柱结核外科手术植骨材料研究进展[J]. 华中科技大学学报(医学版), 2025, 54(2): 290-297.
[19] Zhang, H., Luo, Y., Wang, Y. and Sun, M. (2026) PRP-Related Biomaterials Enhance Bone and Nerve Repair. Materials Today Bio, 36, Article ID: 102656. [Google Scholar] [CrossRef
[20] Garaud, S., Hamard, M., Gorican, K., Bouredoucen, H., Knuchel, C., Ferreira Branco, D., et al. (2026) Pain Induced by Platelet-Rich Plasma Injections: Reality or Myth and Short-Medium Term Efficiency in a Large Retrospective Cohort. Clinical Radiology, 92, Article ID: 107166. [Google Scholar] [CrossRef
[21] Wu, F., Huang, Z., Yang, H. and Huang, H. (2025) Research Progress of Platelet-Rich Plasma in Promoting Peripheral Nerve Repair. Neurogenetics, 26, Article No. 85. [Google Scholar] [CrossRef
[22] Masuki, H., Okudera, T., Watanebe, T., Suzuki, M., Nishiyama, K., Okudera, H., et al. (2016) Growth Factor and Pro-Inflammatory Cytokine Contents in Platelet-Rich Plasma (PRP), Plasma Rich in Growth Factors (PRGF), Advanced Platelet-Rich Fibrin (A-PRF), and Concentrated Growth Factors (CGF). International Journal of Implant Dentistry, 2, Article No. 19. [Google Scholar] [CrossRef] [PubMed]
[23] Karimi, K. and Rockwell, H. (2019) The Benefits of Platelet-Rich Fibrin. Facial Plastic Surgery Clinics of North America, 27, 331-340. [Google Scholar] [CrossRef] [PubMed]
[24] Zwittnig, K., Mukaddam, K., Vegh, D., Herber, V., Jakse, N., Schlenke, P., et al. (2023) Platelet-Rich Fibrin in Oral Surgery and Implantology: A Narrative Review. Transfusion Medicine and Hemotherapy, 50, 348-359. [Google Scholar] [CrossRef] [PubMed]
[25] Ghanaati, S., Booms, P., Orlowska, A., Kubesch, A., Lorenz, J., Rutkowski, J., et al. (2014) Advanced Platelet-Rich Fibrin: A New Concept for Cell-Based Tissue Engineering by Means of Inflammatory Cells. Journal of Oral Implantology, 40, 679-689. [Google Scholar] [CrossRef] [PubMed]
[26] Choukroun, J. and Ghanaati, S. (2018) Reduction of Relative Centrifugation Force within Injectable Platelet-Rich-Fibrin (PRF) Concentrates Advances Patients’ Own Inflammatory Cells, Platelets and Growth Factors: The First Introduction to the Low Speed Centrifugation Concept. European Journal of Trauma and Emergency Surgery, 44, 87-95. [Google Scholar] [CrossRef] [PubMed]
[27] Elver, A. and Caymaz, M.G. (2023) Novel Approaches to the Use of Platelet-Rich Fibrin: A Literature Review. The Saudi Dental Journal, 35, 797-802. [Google Scholar] [CrossRef] [PubMed]
[28] Tunalı, M., Özdemir, H., Küçükodacı, Z., Akman, S., Yaprak, E., Toker, H., et al. (2014) A Novel Platelet Concentrate: Titanium-Prepared Platelet-Rich Fibrin. BioMed Research International, 2014, Article ID: 209548. [Google Scholar] [CrossRef] [PubMed]
[29] Walch, B., Kolk, A., Scheibl, D., Guarda, M., Maier, S.C. and Denk, L. (2024) The Effect of Advanced Platelet-Rich Fibrin Plus (A-PRF+) on Graft Stability in Dental Implants and Alveolar Ridge Augmentation Procedures: A New Low-Speed Standardized Centrifugation Protocol. Dentistry Journal, 12, Article 349. [Google Scholar] [CrossRef] [PubMed]
[30] Yuan, B., He, C. and Lai, W. (2025) Clinical Effect of CGF Blood Concentration Factor in Extracting Supernumerary Teeth in the Middle and High Positions of the Upper Palate. SLAS Technology, 33, Article ID: 100321. [Google Scholar] [CrossRef] [PubMed]
[31] Çolak, R., Özçelik, N. and Küçükoğlu Çolak, M. (2025) Evaluation of Palatal Donor Site Wound Healing with Concentrated Growth Factor after Gingival Graft Procedures. BMC Oral Health, 25, Article No. 1642. [Google Scholar] [CrossRef
[32] Shahood, B., Harphoush, S., Muhaisen, B.O.M. and Qiu, J. (2024) CGF with Bio-Oss Collagen as Grafting Materials for Simultaneous Implant Placement after Osteotome Sinus Floor Elevation: A Prospective Study. BMC Oral Health, 24, Article No. 1515. [Google Scholar] [CrossRef] [PubMed]
[33] Xie, Y., Qin, Y., Wei, M. and Niu, W. (2024) Application of Sticky Bone Combined with Concentrated Growth Factor (CGF) for Horizontal Alveolar Ridge Augmentation of Anterior Teeth: A Randomized Controlled Clinical Study. BMC Oral Health, 24, Article No. 431. [Google Scholar] [CrossRef] [PubMed]
[34] Wei, X.Q., Zhang, S. and Ba, K. (2025) [Evaluation of the Clinical Effect of Concentrated Growth Factor Combined with Sticky Bone in Maxillary Anterior Alveolar Ridge Preservation]. West China Journal of Stomatology, 43, 671-678. (In Chinese)
[35] 刘璐, 刘玉凤, 武芊芊. 自体富血小板血浆联合牙周引导组织再生技术对齿槽嵴裂患者修复效果影响及应用价值分析[J]. 临床和实验医学杂志, 2021, 20(22): 2449-2452.
[36] 周瑛, 闵重函, 张枢宏, 等. 富血小板血浆联合同种异体骨骨粉与自体髂骨移植治疗老年上颌骨骨缺损的效果比较[J]. 浙江医学, 2020, 42(11): 1172-1176.
[37] 杨晶晶, 柴显达. ABB配合PRP促进即刻种植体周骨生长重建的效果评价[J]. 吉林医学, 2014, 35(21): 4611-4612.
[38] 吴萃, 杨敏. 富小血板血浆在口腔种植骨量不足中应用的临床研究[J]. 中国药物与临床, 2018, 18(10): 1793-1795.
[39] 陈铁楼, 王世峰, 刘国勤, 等. 富血小板血浆与多孔矿化骨修复兔下颌骨双皮质骨缺损作用[J]. 口腔医学, 2013, 33(11): 743-747.
[40] 钱文慧, 徐艳, 孙颖, 等. 富血小板血浆修复牙周骨缺损的临床疗效[J]. 牙体牙髓牙周病学杂志, 2014, 24(7): 415-418.
[41] Weibrich, G., Hansen, T., Kleis, W., Buch, R. and Hitzler, W.E. (2004) Effect of Platelet Concentration in Platelet-Rich Plasma on Peri-Implant Bone Regeneration. Bone, 34, 665-671. [Google Scholar] [CrossRef] [PubMed]
[42] Nagrani, T., Kumar, S., Haq, M.A., Dhanasekaran, S., Gajjar, S., Patel, C., et al. (2023) Use of Injectable Platelet-Rich Fibrin Accompanied by Bone Graft in Socket Endurance: A Radiographic and Histological Study. Cureus, 15, e46909. [Google Scholar] [CrossRef] [PubMed]
[43] Kapa, B.P., N.K., S., G.V., G. and Mehta, D.S. (2022) Coronally Advanced Flap Combined with Sticky Bone and I‐PRF‐Coated Collagen Membrane to Treat Single Maxillary Gingival Recessions: Case Series. Clinical Advances in Periodontics, 12, 147-151. [Google Scholar] [CrossRef] [PubMed]
[44] van Orten, A., Goetz, W. and Bilhan, H. (2022) Tooth-Derived Granules in Combination with Platelet-Rich Fibrin (“Sticky Tooth”) in Socket Preservation: A Histological Evaluation. Dentistry Journal, 10, Article 29. [Google Scholar] [CrossRef] [PubMed]
[45] 杜健伟. 注射型富血小板纤维蛋白联合牙本质颗粒在引导骨再生中的应用[D]: [硕士学位论文]. 大连: 大连医科大学, 2024.
[46] Andrade, C., Camino, J., Nally, M., Quirynen, M., Martínez, B. and Pinto, N. (2020) Combining Autologous Particulate Dentin, L-PRF, and Fibrinogen to Create a Matrix for Predictable Ridge Preservation: A Pilot Clinical Study. Clinical Oral Investigations, 24, 1151-1160. [Google Scholar] [CrossRef] [PubMed]
[47] Stanciugelu, S.I., Patrascu, J.M., Florescu, S. and Marian, C. (2024) Sticky Bone as a New Type of Autologous Bone Grafting in Schatzker Type II Tibial Plateau Fracture Case Report. Life, 14, 1042. [Google Scholar] [CrossRef] [PubMed]
[48] Csönge, L., Bozsik, Á., Tóth-Bagi, Z., Gyuris, R. and Kónya, J. (2021) Regenerative Medicine: Characterization of Human Bone Matrix Gelatin (BMG) and Folded Platelet-Rich Fibrin (F-PRF) Membranes Alone and in Combination (Sticky Bone). Cell and Tissue Banking, 22, 711-717. [Google Scholar] [CrossRef] [PubMed]
[49] David, P., Diego, F., Tali, C,. et al. (2023) Sustainability and Release Pattern of Growth Factors from Bone Grafts Prepared with Platelet-Rich Fibrin. The International Journal of Oral & Maxillofacial Implants, 21, 473-478.
[50] Park, J., Hong, K., Ko, K., Cha, J., Gruber, R. and Lee, J. (2022) Platelet‐Rich Fibrin Combined with a Particulate Bone Substitute versus Guided Bone Regeneration in the Damaged Extraction Socket: An in Vivo Study. Journal of Clinical Periodontology, 50, 358-367. [Google Scholar] [CrossRef] [PubMed]
[51] Soni, R., Priya, A., Yadav, H., Mishra, N. and Kumar, L. (2019) Bone Augmentation with Sticky Bone and Platelet-Rich Fibrin by Ridge-Split Technique and Nasal Floor Engagement for Immediate Loading of Dental Implant after Extracting Impacted Canine. National Journal of Maxillofacial Surgery, 10, 98-101. [Google Scholar] [CrossRef] [PubMed]
[52] 李嘉, 肖宇, 曾腾幡, 等. 黏性骨在磨牙牙槽嵴位点保存的临床效果观察[J]. 口腔颌面修复学杂志, 2024, 25(4): 253-258.
[53] Ponte, J., Pérez-Guerrero, J., Aragão, F., Menezes, Y., Melo, M. and Castro-Silva, I. (2021) Histomorphometric Evaluation of Human Extraction Sockets Treated with Autologous Fibrin, Sticky Bone or Biphasic Calcium Phosphate. Acta Odontológica Latinoamericana, 34, 271-281. [Google Scholar] [CrossRef] [PubMed]
[54] Ponte, J.S., Araújo, M.A.D., Araújo, L.K. and Castro-Silva, I.I. (2019) Platelet-Rich Fibrin: A Versatile Purpose for Alveolar Ridge Preservation. Dental Oral Biology and Craniofacial Research, 2, 2-3.
[55] Castro-Silva, I.I. (2018) Platelet-Rich Fibrin for Bone Tissue Regeneration. Otorhinolaryngology-Head and Neck Surgery, 3, 1. [Google Scholar] [CrossRef
[56] 李天一, 张新风, 司亚萌, 等. 超声骨刀骨窗技术联合黏性骨在下颌骨囊肿中的应用研究[J]. 现代生物医学进展, 2025, 25(12): 2024-2033.
[57] 曾千情, 苏浩宇, 汪鼎傑, 等. 浓缩生长因子为基质的黏性骨块在上颌前牙区水平骨增量中应用效果研究[J]. 中国实用口腔科杂志, 2023, 16(3): 320-325.
[58] 刘秉尧, 虞晓东, 李翠梅, 等. A-PRF、CGF结合纳米羟基磷灰石在上颌窦外提升种植术中的应用效果[J]. 上海口腔医学, 2025, 34(1): 43-47.