基于泛素化修饰的中药干预疾病靶标机制研究进展综述
Advances in Mechanism Research of Traditional Chinese Medicine Targeting Diseases via Ubiquitination Modification
DOI: 10.12677/acm.2026.1672523, PDF,   
作者: 蒋桢怡*, 曾令翰*, 欧展瑜#：广西医科大学肿瘤医学院，广西 南宁；杨通艳：桂林医科大学第二临床医学院，广西 桂林
关键词: 泛素化修饰；中药；疾病靶标；E3泛素连接酶；去泛素化酶；分子机制；Ubiquitination Modification； Traditional Chinese Medicine； Disease Target； E3 Ubiquitin Ligase； Deubiquitinase； Molecular Mechanism
摘要: 泛素化修饰作为蛋白质翻译后修饰的核心机制，在细胞周期调控、信号转导、免疫应答及疾病发生发展中发挥着关键作用。近年来，中药活性成分通过调控泛素–蛋白酶体系统(UPS)干预疾病靶标的研究日益深入，为揭示中药多靶点、多途径的作用机制提供了全新视角。本文系统综述了泛素化修饰的基本过程及其在肿瘤、神经退行性疾病、炎症性疾病中的病理意义，重点分析了中药单体及复方通过调节E3泛素连接酶、去泛素化酶及底物蛋白泛素化水平干预疾病靶标的分子机制，并探讨了基于泛素化修饰的中药研究策略与未来方向，旨在为中药现代化研究及新药开发提供理论依据。
Abstract: As a core post-translational modification mechanism of proteins, ubiquitination plays a vital role in cell cycle regulation, signal transduction, immune response and disease pathogenesis. In recent years, studies on the intervention of disease targets by active ingredients of traditional Chinese medicine via regulating the ubiquitin-proteasome system (UPS) have advanced steadily, offering a novel perspective to elucidate the multi-target and multi-pathway pharmacological mechanisms of traditional Chinese medicine. This paper systematically reviews the fundamental process of ubiquitination and its pathological implications in tumors, neurodegenerative diseases and inflammatory diseases. It mainly analyzes the molecular mechanisms by which Chinese medicinal monomers and formulas interfere with disease targets through modulating E3 ubiquitin ligases, deubiquitinases and the ubiquitination level of substrate proteins. Furthermore, research strategies and future prospects of traditional Chinese medicine based on ubiquitination modification are discussed, aiming to provide theoretical references for the modernization research and new drug development of traditional Chinese medicine.
文章引用：蒋桢怡, 曾令翰, 杨通艳, 欧展瑜. 基于泛素化修饰的中药干预疾病靶标机制研究进展综述[J]. 临床医学进展, 2026, 16(7): 262-274. https://doi.org/10.12677/acm.2026.1672523

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