免疫细胞作用于代谢综合征的研究进展
Research Progress on the Action of Immune Cells in Metabolic Syndrome
DOI: 10.12677/acm.2026.1672537, PDF,    科研立项经费支持
作者: 陈 翀, 王爱萍*, 王玉玲：昆明市第一人民医院儿童生长发育管理科室，云南 昆明
关键词: 代谢综合征；免疫细胞；胰岛素抵抗；慢性低度炎症；Metabolic Syndrome； Immune Cells； Insulin Resistance； Chronic Low-Grade Inflammation
摘要: 代谢综合征是一种复杂的代谢紊乱，它通常表现为肥胖，高血压，血脂异常，胰岛素抵抗等，也高风险发展为2型糖尿病、心血管疾病和癌症。此外，由于缺乏有效治疗，代谢疾病的发病率在全球范围内上升。与代谢功能障碍相关的因素有很多，持续未解决的慢性低度炎症是代谢综合征的核心特征之一。这种持续慢性低度炎症与免疫细胞密切相关，并起着关键作用，但其具体作用机制仍未完全明确。本综述探讨了各免疫细胞作用于代谢综合征的研究进展，期望为代谢综合征的防治寻找潜在治疗靶点。
Abstract: Metabolic syndrome is a complex metabolic disorder, which is usually manifested as obesity, hypertension, dyslipidemia, insulin resistance, etc., and is also at high risk of developing type 2 diabetes, cardiovascular diseases and cancer. In addition, due to the lack of effective treatment, the incidence of metabolic diseases is on the rise worldwide. There are many factors related to metabolic dysfunction. Persistent and unresolved chronic low-grade inflammation is one of the core characteristics of metabolic syndrome. This persistent chronic low-grade inflammation is closely related to immune cells and plays a key role, but its specific mechanism of action remains completely unclear. This review explores the research progress of various immune cells acting on metabolic syndrome, with the aim of identifying potential therapeutic targets for the prevention and treatment of metabolic syndrome.
文章引用：陈翀, 王爱萍, 王玉玲. 免疫细胞作用于代谢综合征的研究进展[J]. 临床医学进展, 2026, 16(7): 381-388. https://doi.org/10.12677/acm.2026.1672537

参考文献

[1] Ye, Z., Li, Y., Yang, X., Li, C., Yu, R., Zheng, G., et al. (2025) Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals. Cell Proliferation, 58, e70012. [Google Scholar] [CrossRef] [PubMed]
[2] Sheng, J., Ruedl, C. and Karjalainen, K. (2015) Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells. Immunity, 43, 382-393. [Google Scholar] [CrossRef] [PubMed]
[3] Funes, S.C., Rios, M., Escobar‐Vera, J. and Kalergis, A.M. (2018) Implications of Macrophage Polarization in Autoimmunity. Immunology, 154, 186-195. [Google Scholar] [CrossRef] [PubMed]
[4] Saberi, M., Woods, N.B., de Luca, C., Schenk, S., Lu, J.C., Bandyopadhyay, G., et al. (2009) Hematopoietic Cell-Specific Deletion of Toll-Like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice. Cell Metabolism, 10, 419-429. [Google Scholar] [CrossRef] [PubMed]
[5] Altalhi, R., Pechlivani, N. and Ajjan, R.A. (2021) PAI-1 in Diabetes: Pathophysiology and Role as a Therapeutic Target. International Journal of Molecular Sciences, 22, Article No. 3170. [Google Scholar] [CrossRef] [PubMed]
[6] Lanthier, N., Molendi-Coste, O., Horsmans, Y., van Rooijen, N., Cani, P.D. and Leclercq, I.A. (2010) Kupffer Cell Activation Is a Causal Factor for Hepatic Insulin Resistance. American Journal of Physiology-Gastrointestinal and Liver Physiology, 298, G107-G116. [Google Scholar] [CrossRef] [PubMed]
[7] Takikawa, A., Mahmood, A., Nawaz, A., Kado, T., Okabe, K., Yamamoto, S., et al. (2016) HIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling toward Insulin Resistance. Diabetes, 65, 3649-3659. [Google Scholar] [CrossRef] [PubMed]
[8] Wen, Y., Lambrecht, J., Ju, C. and Tacke, F. (2021) Hepatic Macrophages in Liver Homeostasis and Diseases-Diversity, Plasticity and Therapeutic Opportunities. Cellular & Molecular Immunology, 18, 45-56. [Google Scholar] [CrossRef] [PubMed]
[9] Rocha, V.Z., Folco, E.J., Sukhova, G., Shimizu, K., Gotsman, I., Vernon, A.H., et al. (2008) Interferon-γ, a Th1 Cytokine, Regulates Fat Inflammation: A Role for Adaptive Immunity in Obesity. Circulation Research, 103, 467-476. [Google Scholar] [CrossRef] [PubMed]
[10] Zhang, H., Potter, B.J., Cao, J. and Zhang, C. (2011) Interferon-Gamma Induced Adipose Tissue Inflammation Is Linked to Endothelial Dysfunction in Type 2 Diabetic Mice. Basic Research in Cardiology, 106, 1135-1145. [Google Scholar] [CrossRef] [PubMed]
[11] Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., et al. (2009) CD8+ Effector T Cells Contribute to Macrophage Recruitment and Adipose Tissue Inflammation in Obesity. Nature Medicine, 15, 914-920. [Google Scholar] [CrossRef] [PubMed]
[12] Toubal, A., Kiaf, B., Beaudoin, L., Cagninacci, L., Rhimi, M., Fruchet, B., et al. (2020) Mucosal-Associated Invariant T Cells Promote Inflammation and Intestinal Dysbiosis Leading to Metabolic Dysfunction during Obesity. Nature Communications, 11, Article No. 3755. [Google Scholar] [CrossRef] [PubMed]
[13] Cipolletta, D., Feuerer, M., Li, A., Kamei, N., Lee, J., Shoelson, S.E., et al. (2012) PPAR-γ Is a Major Driver of the Accumulation and Phenotype of Adipose Tissue Treg Cells. Nature, 486, 549-553. [Google Scholar] [CrossRef] [PubMed]
[14] Winer, D.A., Winer, S., Shen, L., Wadia, P.P., Yantha, J., Paltser, G., et al. (2011) B Cells Promote Insulin Resistance through Modulation of T Cells and Production of Pathogenic IGG Antibodies. Nature Medicine, 17, 610-617. [Google Scholar] [CrossRef] [PubMed]
[15] Wouters, K., Kusters, Y.H.A.M., Bijnen, M., Wetzels, S., Zhang, X., Linssen, P.B.C., et al. (2020) NK Cells in Human Visceral Adipose Tissue Contribute to Obesity‐Associated Insulin Resistance through Low‐Grade Inflammation. Clinical and Translational Medicine, 10, e192. [Google Scholar] [CrossRef] [PubMed]
[16] Andersen, C.J., Murphy, K.E. and Fernandez, M.L. (2016) Impact of Obesity and Metabolic Syndrome on Immunity. Advances in Nutrition, 7, 66-75. [Google Scholar] [CrossRef] [PubMed]
[17] Liu, L., Hu, J., Wang, Y., Lei, H. and Xu, D. (2021) The Role and Research Progress of the Balance and Interaction between Regulatory T Cells and Other Immune Cells in Obesity with Insulin Resistance. Adipocyte, 10, 66-79. [Google Scholar] [CrossRef] [PubMed]
[18] Eller, K., Kirsch, A., Wolf, A.M., Sopper, S., Tagwerker, A., Stanzl, U., et al. (2011) Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy. Diabetes, 60, 2954-2962. [Google Scholar] [CrossRef] [PubMed]
[19] Schmidleithner, L., Thabet, Y., Schönfeld, E., et al. (2019) Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction. Immunity, 50, 1232-1248.e14.
[20] Palatucci, A.T., Piantedosi, D., Rubino, V., Giovazzino, A., Guccione, J., Pernice, V., et al. (2018) Circulating Regulatory T Cells (Treg), Leptin and Induction of Proinflammatory Activity in Obese Labrador Retriever Dogs. Veterinary Immunology and Immunopathology, 202, 122-129. [Google Scholar] [CrossRef] [PubMed]
[21] Gilleron, J., Bouget, G., Ivanov, S., Meziat, C., Ceppo, F., Vergoni, B., et al. (2018) Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance. Cell Reports, 25, 3329-3341.e5. [Google Scholar] [CrossRef] [PubMed]
[22] Zhong, J., Rao, X., Braunstein, Z., Taylor, A., Narula, V., Hazey, J., et al. (2014) T-Cell Costimulation Protects Obesity-Induced Adipose Inflammation and Insulin Resistance. Diabetes, 63, 1289-1302. [Google Scholar] [CrossRef] [PubMed]
[23] Yu, W., Li, C., Zhang, D., Li, Z., Xia, P., Liu, X., et al. (2022) Advances in T Cells Based on Inflammation in Metabolic Diseases. Cells, 11, Article No. 3554. [Google Scholar] [CrossRef] [PubMed]
[24] Bertola, A., Ciucci, T., Rousseau, D., Bourlier, V., Duffaut, C., Bonnafous, S., et al. (2012) Identification of Adipose Tissue Dendritic Cells Correlated with Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients. Diabetes, 61, 2238-2247. [Google Scholar] [CrossRef] [PubMed]
[25] Macdougall, C.E., Wood, E.G., Loschko, J., Scagliotti, V., Cassidy, F.C., Robinson, M.E., et al. (2018) Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets. Cell Metabolism, 27, 588-601.e4. [Google Scholar] [CrossRef] [PubMed]
[26] Wu, D., Molofsky, A.B., Liang, H., Ricardo-Gonzalez, R.R., Jouihan, H.A., Bando, J.K., et al. (2011) Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis. Science, 332, 243-247. [Google Scholar] [CrossRef] [PubMed]
[27] Lee, E.H., Itan, M., Jang, J., Gu, H., Rozenberg, P., Mingler, M.K., et al. (2018) Eosinophils Support Adipocyte Maturation and Promote Glucose Tolerance in Obesity. Scientific Reports, 8, Article No. 9894. [Google Scholar] [CrossRef] [PubMed]
[28] Meier, D.T., de Paula Souza, J. and Donath, M.Y. (2025) Targeting the NLRP3 Inflammasome-IL-1β Pathway in Type 2 Diabetes and Obesity. Diabetologia, 68, 3-16. [Google Scholar] [CrossRef] [PubMed]
[29] Srikanthan, K., Feyh, A., Visweshwar, H., Shapiro, J.I. and Sodhi, K. (2016) Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population. International Journal of Medical Sciences, 13, 25-38. [Google Scholar] [CrossRef] [PubMed]

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